| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5249727 | B | Displacement of 12G5 mAb from CXCR4 (unknown origin) expressed in CHO cells incubated for 40 mins by spectrophotometric method | Homo sapiens | 10 | ALA5247608 | cell-based format | Scientific Literature | |
| 2. | ALA5249729 | B | Antagonist activity against CXCR4 in human SUP-T1 cells assessed as inhibition of SDF-1alpha-induced intracellular calcium mobilization by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 3. | ALA5249730 | B | Antagonist activity against CXCR4 in human SUP-T1 cells assessed as inhibition of SDF-1alpha-induced intracellular calcium mobilization at 10 uM by Fluo-4AM dye based fluorescence analysis | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 4. | ALA5249731 | B | Antagonist activity against CXCR4 in human SUP-T1 cells assessed as inhibition of SDF-1alpha-induced cell migration preincubated with cells for 30 mins followed by incubation with SDF-1alpha for 3 hrs by CellTiter-96 reagent based transwell assay | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 5. | ALA5249732 | B | Antagonist activity against CXCR4 in human SUP-T1 cells assessed as inhibition of SDF-1alpha-induced cell migration at 10 uM preincubated with cells for 30 mins followed by incubation with SDF-1alpha for 3 hrs by CellTiter-96 reagent based transwell assay | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 6. | ALA5249733 | B | Antagonist activity against EGFP-tagged CXCR4 (unknown origin) transfected in CHO cells assessed as inhibition of SDF-1alpha-induced receptor internalization at 0.01 to 10 uM preincubated for 10 mins followed by SDF-1alpha addition by confocal microscopy | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 7. | ALA5249734 | B | Antagonist activity against EGFP-tagged CXCR4 (unknown origin) transfected in CHO cells assessed as inhibition of SDF-1alpha-induced receptor internalization at 10 uM preincubated for 10 mins followed by SDF-1alpha addition by confocal microscopy | Homo sapiens | 2 | ALA5247608 | cell-based format | Scientific Literature | |
| 8. | ALA5249735 | F | Antiviral activity against HIV-1 X4 NL4-3 infected in human PBMC assessed as inhibition of viral replication by measuring reduction in p24 antigen level at 10 uM measured after 5 days by ELISA | Human immunodeficiency virus 1 | 4 | ALA5247608 | organism-based format | Scientific Literature | |
| 9. | ALA5249737 | F | Antiviral activity against HIV-1 R5 Bal-6 infected in human PBMC assessed as inhibition of viral replication by measuring reduction in p24 antigen level at 10 uM measured after 5 days by ELISA | Human immunodeficiency virus 1 | 1 | ALA5247608 | organism-based format | Scientific Literature | |
| 10. | ALA5249739 | T | Cytotoxicity against human PBMC assessed as reduction in cell viability at 0.016 to 10 uM incubated for 5 days by CellTiter-Blue assay | Homo sapiens | 4 | ALA5247608 | cell-based format | Scientific Literature | |
| 11. | ALA5249755 | B | Displacement of 12G5 mAb from CXCR4 F87A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 12. | ALA5249756 | B | Displacement of 12G5 mAb from CXCR4 W94A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 13. | ALA5249757 | B | Displacement of 12G5 mAb from CXCR4 N119A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 14. | ALA5249758 | B | Displacement of 12G5 mAb from CXCR4 H113A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 15. | ALA5249759 | B | Displacement of 12G5 mAb from CXCR4 W161A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 16. | ALA5249760 | B | Displacement of 12G5 mAb from CXCR4 D193A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 17. | ALA5249761 | B | Displacement of 12G5 mAb from CXCR4 W195A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 18. | ALA5249762 | B | Displacement of 12G5 mAb from CXCR4 D262N mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 19. | ALA5249763 | B | Displacement of 12G5 mAb from CXCR4 E288A mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature | |
| 20. | ALA5249764 | B | Displacement of 12G5 mAb from CXCR4 E288D mutant (unknown origin) expressed in CHO cells at 200 nM incubated for 40 mins by spectrophotometric method | Homo sapiens | 1 | ALA5247608 | cell-based format | Scientific Literature |
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