| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5243881 | P | 1-Octanol/aqueous buffer partition coefficient, logD of the compound at pH 7.4 by chromatographic method based UV-visible detector | 18 | ALA5241126 | small-molecule physicochemical format | Scientific Literature | ||
| 2. | ALA5243882 | B | Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 18 | ALA5241126 | cell-based format | Scientific Literature | |
| 3. | ALA5243883 | B | Positive allosteric modulator activity at GluN2A NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay relative to control | Homo sapiens | 18 | ALA5241126 | cell-based format | Scientific Literature | |
| 4. | ALA5243884 | B | Displacement of [3H]-HBT1 from His-tagged GluA2-AMPA receptor LBD (unknown origin) in presence of glutamate by scintillation proximity assay | Homo sapiens | 17 | ALA5241126 | single protein format | Scientific Literature | |
| 5. | ALA5243885 | A | Metabolic stability in human liver microsomes assessed as clearance at 1 uM incubated for 15 to 30 mins in the presence of NADPH generating system by LC-MS/MS analysis | Homo sapiens | 8 | ALA5241126 | microsome format | Scientific Literature | |
| 6. | ALA5243886 | A | Metabolic stability in rat liver microsomes assessed as clearance at 1 uM incubated for 15 to 30 mins in the presence of NADPH generating system by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA5241126 | microsome format | Scientific Literature | |
| 7. | ALA5243887 | B | Positive allosteric modulator activity at GluN2B NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 8. | ALA5243888 | B | Positive allosteric modulator activity at GluN2B NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 9. | ALA5243889 | B | Positive allosteric modulator activity at GluN2C NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 10. | ALA5243890 | B | Positive allosteric modulator activity at GluN2C NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 11. | ALA5243891 | B | Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 12. | ALA5243892 | B | Positive allosteric modulator activity at GluN2D NMDA receptor (unknown origin) expressed in CHO cells co-expressing GluN1a assessed as maximum potentiation at 30 uM in the presence of L-glutamate and glycine by Ca2+ influx assay | Homo sapiens | 1 | ALA5241126 | cell-based format | Scientific Literature | |
| 13. | ALA5243893 | A | Drug concentration in Sprague-Dawley rat plasma at 10 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 14. | ALA5243894 | A | Drug concentration in Sprague-Dawley rat brain at 10 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 15. | ALA5243895 | A | Ratio of drug concentration in brain to plasma of Sprague-Dawley rat at 10 mg/kg, po measured after 0.5 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 16. | ALA5243896 | A | Drug concentration in Sprague-Dawley rat plasma at 10 mg/kg, po measured after 1 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 17. | ALA5243897 | A | Drug concentration in Sprague-Dawley rat brain at 10 mg/kg, po measured after 1 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 18. | ALA5243898 | A | Ratio of drug concentration in brain to plasma of Sprague-Dawley rat at 10 mg/kg, po measured after 1 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 19. | ALA5243899 | A | Drug concentration in Sprague-Dawley rat plasma at 10 mg/kg, po measured after 2 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature | |
| 20. | ALA5243900 | A | Drug concentration in Sprague-Dawley rat brain at 10 mg/kg, po measured after 2 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5241126 | organism-based format | Scientific Literature |
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