| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5244397 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA5244398 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 3. | ALA5244399 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA5244400 | A | AUC (0 to 24 hrs) in Sprague-Dawley rat at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA5244401 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA5244402 | A | Half life in Sprague-Dawley rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA5244403 | A | AUC (0 to 24 hrs) in Sprague-Dawley rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA5244404 | A | Oral availability in Sprague-Dawley rat at 1 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA5244405 | A | Tmax in Sprague-Dawley rat at 1 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA5244406 | B | Inhibition of human JAK3 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 11. | ALA5244407 | B | Inhibition of human JAK2 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 12. | ALA5244408 | B | Inhibition of human JAK1 kinase domain using biotin-Lyn-substrate-2 as substrate incubated for 1 hr by ELISA | Homo sapiens | 12 | single protein format | Scientific Literature | ||
| 13. | ALA5244409 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 0.2 uM incubated for 45 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 10 | microsome format | Scientific Literature | ||
| 14. | ALA5244410 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes at 5 uM using midazolam as substrate preincubated for 0 to 30 mins followed by midazolam addition and measured after 20 mins by LC-MS/MS analysis relative to control | Homo sapiens | 13 | microsome format | Scientific Literature | ||
| 15. | ALA5244411 | A | Permeability of the compound in pH 6.5 incubated for 2 hrs by PAMPA based HPLC analysis | 15 | assay format | Scientific Literature | |||
| 16. | ALA5244413 | B | Selectivity index, ratio of IC50 for human JAK3 to IC50 for human JAK2 | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA5244414 | B | Inhibition of ABL (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA5244415 | B | Inhibition of BTK (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA5244416 | B | Inhibition of CSK (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA5244417 | B | Inhibition of EGFR (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!