# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5251798 | B | Induction of SOS1 degradation in human NCI-H358 cells at 0.1 to 1 uM incubated for 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA5251801 | B | Binding affinity to GST tagged human SOS1(564 to 1049 residues)-6his tagged human VHL (54 to 213 residues)-human ElonginC (17 to 112 residues)-human ElonginB (1 to 104 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as ternary complex formation by measuring maximal HTRF signals incubated for 15 mins by HTRF analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
3. | ALA5251802 | B | Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as binary complex formation by measuring dissociation constant incubated for 15 mins by fluorescence polarization-based displacement assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
4. | ALA5251803 | B | Binding affinity to GST-tagged human SOS1 (564 to 1049 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as ternary complex formation by measuring dissociation constant incubated for 15 mins in the presence of 6His tagged human VCB by fluorescence polarization-based displacement assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
5. | ALA5251851 | F | Antiproliferative activity against human MIA PaCa-2 cells harboring KRAS G12C mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
6. | ALA5251852 | F | Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
7. | ALA5251853 | F | Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
8. | ALA5251854 | F | Antiproliferative activity against human PANC-1 cells harboring KRAS G12D mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
9. | ALA5251855 | F | Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA5251856 | F | Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
11. | ALA5251857 | F | Antiproliferative activity against human LoVo cells harboring KRAS G13D mutant assessed as inhibition of cell proliferation incubated for 7 days by CellTiterGlo-3D proliferation assay | Homo sapiens | 4 | cell-based format | Scientific Literature |