| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5226037 | B | Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and measured after 30 mins by HTRF assay | Homo sapiens | 25 | ALA5223180 | single protein format | Scientific Literature | |
| 2. | ALA5226038 | F | Antiproliferative activity against human MIA PaCa-2 cells harboring G12C mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 12 | ALA5223180 | cell-based format | Scientific Literature | |
| 3. | ALA5226039 | F | Antiproliferative activity against human MIA PaCa-2 cells harboring G12C mutant assessed as cell growth inhibition at high concentration incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 12 | ALA5223180 | cell-based format | Scientific Literature | |
| 4. | ALA5226040 | B | Inhibition of FGFR1 (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 5. | ALA5226041 | B | Inhibition of EGFR (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 6. | ALA5226042 | B | Inhibition of HER2 (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 7. | ALA5226043 | B | Inhibition of PDGFRalpha (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 8. | ALA5226044 | B | Inhibition of CDK2 (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 9. | ALA5226045 | B | Inhibition of CDK4 (unknown origin) | Homo sapiens | 1 | ALA5223180 | single protein format | Scientific Literature | |
| 10. | ALA5226046 | F | Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 11. | ALA5226047 | F | Antiproliferative activity against human ASPC1 cells harboring KRAS G12D mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 12. | ALA5226048 | F | Antiproliferative activity against human PANC-1 cells harboring KRAS G12D mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 13. | ALA5226049 | F | Antiproliferative activity against human SW620 cells harboring KRAS G12V mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 14. | ALA5226050 | F | Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 15. | ALA5226051 | F | Antiproliferative activity against human A-375 cells harboring wild type KRAS assessed as cell growth inhibition incubated for 7 days by Celltiter-Glo 3D cell viability assay | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 16. | ALA5226052 | B | Inhibition of KRAS G12D mutant in human ASPC1 cells assessed as reduction in ERK phosphorylation after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 17. | ALA5226053 | B | Inhibition of KRAS G12D mutant in human ASPC1 cells assessed as reduction in AKT phosphorylation after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 18. | ALA5226054 | B | Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in ERK phosphorylation at 100 to 1000 nM after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 19. | ALA5226055 | B | Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in AKT phosphorylation at 100 to 1000 nM after 2 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature | |
| 20. | ALA5226056 | F | Antiproliferative activity against human MIA PaCa-2 cells harboring G12C mutant assessed as cell growth inhibition at 3.9 nM incubated for 7 days in presence of 1.3 nM MRTX849 by Celltiter-Glo 3D cell viability assay (Rvb = 2.9 %) | Homo sapiens | 1 | ALA5223180 | cell-based format | Scientific Literature |
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