# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5252012 | Binding | Inhibition of N-terminal 6-His tagged human recombinant GSK3-beta H355L mutant using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrs | Homo sapiens | 32 | ALA5247659 | assay format | Scientific Literature | |
2. | ALA5252013 | Binding | Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrs | Homo sapiens | 32 | ALA5247659 | single protein format | Scientific Literature | |
3. | ALA5252014 | Binding | Inhibition of tau 4R1N phosphorylation (unknown origin) at S396 residue transfected in human U2OS cells coexpressing GFP-tagged beta catenin incubated overnight by high content imaging assay | Homo sapiens | 12 | ALA5247659 | cell-based format | Scientific Literature | |
4. | ALA5252023 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA5247659 | microsome format | Scientific Literature | |
5. | ALA5252024 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM incubated for 10 mins by LC-MS/MS analysis | Mus musculus | 6 | ALA5247659 | microsome format | Scientific Literature | |
6. | ALA5252027 | ADME | Plasma protein binding in mouse assessed as unbound fraction at 10 uM measured for 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Mus musculus | 6 | ALA5247659 | cell-free format | Scientific Literature | |
7. | ALA5252028 | ADME | Plasma protein binding in human assessed as unbound fraction at 10 uM measured for 5 hrs by equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 6 | ALA5247659 | cell-free format | Scientific Literature | |
8. | ALA5252029 | ADME | Permeability of compound at pH 5.5 incubated for 4 hrs by PAMPA assay | 6 | ALA5247659 | assay format | Scientific Literature | ||
9. | ALA5252030 | ADME | Permeability of compound at pH 7.4 incubated for 4 hrs by PAMPA assay | 6 | ALA5247659 | assay format | Scientific Literature | ||
10. | ALA5252031 | ADME | Permeability across apical to basolateral side in human Caco-2 cells at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | ALA5247659 | cell-based format | Scientific Literature | |
11. | ALA5252032 | ADME | Permeability across basolateral to apical side in human Caco-2 cells at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 6 | ALA5247659 | cell-based format | Scientific Literature | |
12. | ALA5252035 | ADME | Clearance in 8 hr fasted C57BL6 mouse at 2 mg/kg, iv | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
13. | ALA5252036 | ADME | Volume of distribution at steady state in 8 hr fasted C57BL6 mouse at 2 mg/kg, iv | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
14. | ALA5252037 | ADME | MRT in 8 hr fasted C57BL6 mouse at 2 mg/kg, iv | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
15. | ALA5252038 | ADME | Half life in 8 hr fasted C57BL6 mouse at 2 mg/kg, iv | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
16. | ALA5252039 | ADME | AUC tot in 8 hr fasted C57BL6 mouse at 10 mg/kg, po | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
17. | ALA5252040 | ADME | Cmax in 8 hr fasted C57BL6 mouse at 10 mg/kg, po | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
18. | ALA5252041 | ADME | Oral bioavailability in 8 hr fasted C57BL6 mouse at 10 mg/kg | Mus musculus | 3 | ALA5247659 | organism-based format | Scientific Literature | |
19. | ALA5252073 | ADME | Substrate activity at P-glycoprotein in human Caco-2 cells assessed as efflux ratio of permeability across basolateral to apical side over apical to basolateral side at 3 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA5247659 | cell-based format | Scientific Literature |