Antitumor activity against human MGC-803 cells xenografted in nude mouse assessed as reduction in tumor volume growth rate at 4 mg/kg, ip administrated every other day for 21 days relative to control
Antitumor activity against human MGC-803 cells xenografted in nude mouse assessed as reduction in tumor volume growth rate at 8 mg/kg, ip administrated every other day for 21 days relative to control
Antitumor activity against human MGC-803 cells xenografted in nude mouse assessed as reduction in tumor weight at 4 mg/kg, ip administrated every other day for 21 days relative to control
Antitumor activity against human MGC-803 cells xenografted in nude mouse assessed as reduction in tumor weight at 8 mg/kg, ip administrated every other day for 21 days relative to control
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as effect on body weight at 4 mg/kg, ip administrated every other day measured at 9 to 14 days
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as morphological changes in heart at 8 mg/kg, ip administrated every other day for 21 days
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as morphological changes in liver at 8 mg/kg, ip administrated every other day for 21 days
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as morphological changes in spleen at 8 mg/kg, ip administrated every other day for 21 days
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as morphological changes in lung at 8 mg/kg, ip administrated every other day for 21 days
Toxicity in nude mouse xenografted with human MGC-803 cells assessed as morphological changes in kidney at 8 mg/kg, ip administrated every other day for 21 days
Induction of cell cycle arrest in human CNE-2 cells assessed as accumulation of cells at G1 phase at 0.5 uM measured after 48 hrs by flow cytometry analysis (Rvb= 73.18%)
Induction of cell cycle arrest in human CNE-2 cells assessed as accumulation of cells at G2 phase at 0.5 uM measured after 48 hrs by flow cytometry analysis (Rvb= 6.99%)