| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5233396 | F | Antithrombotic activity in anesthetized Wistar rat model of FeCL3-induced carotid artery thrombosis assessed as reduction in thrombus weight at 10 mg/kg, po administered as single dose measured at 1.5 hrs post dose | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 2. | ALA5233398 | F | Antiplatelet activity in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation by aggregometry | Homo sapiens | 39 | organism-based format | Scientific Literature | ||
| 3. | ALA5233399 | A | Metabolic stability in rat liver microsomes assessed as half life at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 4. | ALA5233400 | A | Metabolic stability in dog liver microsomes assessed as half life at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Canis lupus familiaris | 5 | microsome format | Scientific Literature | ||
| 5. | ALA5233401 | A | Metabolic stability in human liver microsomes assessed as half life at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 6. | ALA5233402 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 7. | ALA5233403 | A | Metabolic stability in dog liver microsomes assessed as intrinsic clearance at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Canis lupus familiaris | 5 | microsome format | Scientific Literature | ||
| 8. | ALA5233404 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 mM measured up to 60 mins in presence of NADPH regeneration system by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 9. | ALA5233405 | A | Cmax in Sprague-Dawley rat at 5 mg/kg,po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 10. | ALA5233406 | A | Half life in Sprague-Dawley rat at 5 mg/kg,po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 11. | ALA5233407 | A | Tmax in Sprague-Dawley rat at 5 mg/kg,po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 12. | ALA5233408 | A | AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg,po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 13. | ALA5233409 | A | MRT in Sprague-Dawley rat at 5 mg/kg,po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 14. | ALA5233410 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 15. | ALA5233411 | A | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 16. | ALA5233412 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 17. | ALA5233413 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 18. | ALA5233414 | A | Inhibition of CYP3A4 in human liver microsomes using Midazolam as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 19. | ALA5233415 | A | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 20. | ALA5233428 | T | Inhibition of human ERG potassium channel at 40 uM at -80 mV holding potential by automated patch clamp assay | Homo sapiens | 4 | assay format | Scientific Literature |
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