# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5228272 | Binding | Inhibition of TNKS1 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA | Homo sapiens | 24 | ALA5226325 | single protein format | Scientific Literature | |
2. | ALA5228273 | Binding | Modulation of Wnt/beta-catenin signaling pathway in human DLD-1 cells assessed as induction of AXIN2 accumulation incubated for 24 hrs by ELISA | Homo sapiens | 24 | ALA5226325 | cell-based format | Scientific Literature | |
3. | ALA5228274 | Physicochemical | Solubility of compound at pH 7.4 | 24 | ALA5226325 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5228276 | ADME | Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg of protein by UPLC analysis | Homo sapiens | 23 | ALA5226325 | microsome format | Scientific Literature | |
5. | ALA5228277 | ADME | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance per mg of protein by UPLC analysis | Mus musculus | 24 | ALA5226325 | microsome format | Scientific Literature | |
6. | ALA5228278 | Binding | Inhibition of TNKS2 (unknown origin) using biotinylated NAD as substrate assessed as inhibition of autoPARsylation activity incubated for 1 hr by ELISA | Homo sapiens | 23 | ALA5226325 | single protein format | Scientific Literature | |
7. | ALA5228279 | Binding | Inhibition of PARP-1 (unknown origin) using biotinylated NAD and NAD as substrate assessed as inhibition of auto-PARsylation incubated for 150 mins by TR-FRET assay | Homo sapiens | 23 | ALA5226325 | single protein format | Scientific Literature | |
8. | ALA5228280 | Physicochemical | Lipophilicity, logD of compound at pH 7.4 | 12 | ALA5226325 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5228283 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells at 1 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA5226325 | cell-based format | Scientific Literature | |
10. | ALA5228284 | ADME | Efflux ratio of apparent permeability across apical to basolateral over basolateral to apical side in human Caco-2 cells at 1 uM incubated for 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA5226325 | cell-based format | Scientific Literature | |
11. | ALA5228285 | ADME | Clearance in mouse plasma | Mus musculus | 4 | ALA5226325 | cell-free format | Scientific Literature |