# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5249576 | B | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | Electrophorus electricus | 33 | ALA5247604 | single protein format | Scientific Literature | |
2. | ALA5249577 | B | Mixed type inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Lineweaver-Burk plot analysis | Electrophorus electricus | 1 | ALA5247604 | single protein format | Scientific Literature | |
3. | ALA5249578 | B | Metal chelating activity assessed as Cu2+-compound complex formation by measuring red shift in presence of CuSO4 at 40 uM incubated for 30 mins by UV-Visible spectrophotometry | 2 | ALA5247604 | assay format | Scientific Literature | ||
4. | ALA5249579 | B | Metal chelating activity assessed as Fe2+-compound complex formation by measuring red shift in presence of FeSO4 at 40 uM incubated for 30 mins by UV-Visible spectrophotometry | 2 | ALA5247604 | assay format | Scientific Literature | ||
5. | ALA5249580 | B | Metal chelating activity assessed as Fe3+-compound complex formation by measuring red shift in presence of FeCl3 at 40 uM incubated for 30 mins by UV-Visible spectrophotometry | 2 | ALA5247604 | assay format | Scientific Literature | ||
6. | ALA5249581 | B | Metal chelating activity assessed as Zn2+-compound complex formation by measuring red shift in presence of ZnCl2 at 40 uM incubated for 30 mins by UV-Visible spectrophotometry | 2 | ALA5247604 | assay format | Scientific Literature | ||
7. | ALA5249582 | B | Metal chelating activity assessed as Al3+-compound complex formation by measuring red shift in presence of AlCl3 at 40 uM incubated for 30 mins by UV-Visible spectrophotometry | 1 | ALA5247604 | assay format | Scientific Literature | ||
8. | ALA5249584 | B | Inhibition of Cu2+ induced amyloid beta (1 to 42 ) (unknown origin) aggregation incubated for 24 hr by Thioflavin T based fluorometric assay | Homo sapiens | 3 | ALA5247604 | single protein format | Scientific Literature | |
9. | ALA5249585 | B | Inhibition of Cu2+ induced amyloid beta (1 to 42 ) (unknown origin) aggregation assessed as reduction in fibrils incubated for 24 hr by TEM analysis | Homo sapiens | 3 | ALA5247604 | single protein format | Scientific Literature | |
10. | ALA5249586 | B | Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregation incubated for 24 hr by Thioflavin T based fluorometric assay | Homo sapiens | 2 | ALA5247604 | single protein format | Scientific Literature | |
11. | ALA5249587 | B | Inhibition of AChE induced HFIP-pretreated amyloid beta (1 to 42 ) (unknown origin) aggregation at 0.1 to 10 uM incubated for 24 hr by Thioflavin T based fluorometric assay | Homo sapiens | 1 | ALA5247604 | single protein format | Scientific Literature | |
12. | ALA5249588 | B | Inhibition of AChE induced HFIP-pretreated amyloid beta (1 to 42 ) (unknown origin) aggregation incubated for 24 hr by Thioflavin T based fluorometric assay | Homo sapiens | 2 | ALA5247604 | single protein format | Scientific Literature | |
13. | ALA5249589 | T | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability upto 50 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA5247604 | cell-based format | Scientific Literature | |
14. | ALA5249590 | B | Inhibition of AChE in human SH-SY5Ycells assessed as reduction AChE activity using acetylthiocholine as substrate at 0.3 to 10 uM incubated for 24 hrs by DTNB based Ellman's method | Homo sapiens | 1 | ALA5247604 | cell-based format | Scientific Literature | |
15. | ALA5249591 | B | Inhibition of AChE in human SH-SY5Ycells assessed as reduction AChE activity using acetylthiocholine as substrate incubated for 24 hrs by DTNB based Ellman's method | Homo sapiens | 2 | ALA5247604 | cell-based format | Scientific Literature | |
16. | ALA5249592 | F | Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of okadaic acid-induced mitochondrial membrane potential by measuring increase in red-to-green fluorescence intensity ratio at 1 to 10 uM pretreated for 24 hrs followed by okadaic acid addition for 24 hrs by JC-1 dye based fluorescence analysis | Homo sapiens | 1 | ALA5247604 | cell-based format | Scientific Literature | |
17. | ALA5249593 | F | Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of okadaic acid-induced mitochondrial membrane potential by measuring increase in red-to-green fluorescence intensity ratio pretreated for 24 hrs followed by okadaic acid addition for 24 hrs by JC-1 dye based fluorescence analysis | Homo sapiens | 2 | ALA5247604 | cell-based format | Scientific Literature | |
18. | ALA5249594 | F | Antioxidant activity against okadaic acid-induced ROS generation in human SH-SY5Y cells assessed as reduction in DCF fluorescence intensity at 1 to 10 uM pretreated for 24 hrs followed by okadaic acid addition for 24 hrs by DCFH-DA dye based fluorescence analysis | Homo sapiens | 2 | ALA5247604 | cell-based format | Scientific Literature | |
19. | ALA5249595 | F | Antioxidant activity against okadaic acid-induced ROS generation in human SH-SY5Y cells assessed as reduction in DCF fluorescence intensity pretreated for 24 hrs followed by okadaic acid addition for 24 hrs by DCFH-DA dye based fluorescence analysis | Homo sapiens | 2 | ALA5247604 | cell-based format | Scientific Literature | |
20. | ALA5249596 | F | Antialzheimer activity in human SH-SY5Y cells assessed as inhibition of GA-induced tau hyperphosphorylation at Ser199 residue at 0.1 to 3 uM incubated for 24 hrs by ELISA | Homo sapiens | 2 | ALA5247604 | cell-based format | Scientific Literature |