| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5251896 | T | Toxicity in dog assessed as increase in heart rate at 500 mg/kg administered as repeated dose for 28 days | Canis lupus familiaris | 1 | ALA5247657 | organism-based format | Scientific Literature | |
| 2. | ALA5251897 | A | Inhibition of CYP2C19 in pooled human liver microsomes using S-mephenytoin as substrate assessed as reduction in OH-S-mephenytoin metabolite formation by LC-MS/MS analysis | Homo sapiens | 1 | ALA5247657 | microsome format | Scientific Literature | |
| 3. | ALA5251898 | B | Selectivity index, ratio of IC50 for inhibition of human NLK to IC50 for inhibition of human BTK | Homo sapiens | 1 | ALA5247657 | assay format | Scientific Literature | |
| 4. | ALA5251899 | B | Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSSARQ-NH2 as substrate preincubated for 1 hrs followed by substrate addition in presence of ATP at Km concentration and measured after 1 hrs by TR-FRET assay | Homo sapiens | 39 | ALA5247657 | cell-based format | Scientific Literature | |
| 5. | ALA5251900 | B | Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 29 | ALA5247657 | single protein format | Scientific Literature | |
| 6. | ALA5251901 | B | Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 29 | ALA5247657 | single protein format | Scientific Literature | |
| 7. | ALA5251903 | B | Selectivity ratio of IC50 for inhibition of EGFR (unknown origin) to IC50 for inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells | Homo sapiens | 6 | ALA5247657 | cell-based format | Scientific Literature | |
| 8. | ALA5251904 | B | Selectivity ratio of IC50 for inhibition of TEC (unknown origin) to IC50 for inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells | Homo sapiens | 8 | ALA5247657 | cell-based format | Scientific Literature | |
| 9. | ALA5251905 | B | Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysis | Homo sapiens | 30 | ALA5247657 | cell-based format | Scientific Literature | |
| 10. | ALA5251907 | F | Antiproliferative activity against human REC1 cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 6 | ALA5247657 | cell-based format | Scientific Literature | |
| 11. | ALA5251908 | F | Antiproliferative activity against human Ramos cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA5247657 | cell-based format | Scientific Literature | |
| 12. | ALA5251909 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability incubated for 6 days by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA5247657 | cell-based format | Scientific Literature | |
| 13. | ALA5251910 | B | Inhibition of human BTK preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 14. | ALA5251911 | B | Inhibition of human TXK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 2 | ALA5247657 | single protein format | Scientific Literature | |
| 15. | ALA5251912 | B | Inhibition of human NLK preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 16. | ALA5251913 | B | Inhibition of human MYO3b preincubated with compound for 1 hrs followed by ATP/33P-ATP addition and measured after 2 hrs by radioactive filter-binding assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 17. | ALA5251914 | B | Inhibition of human EGFR preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 18. | ALA5251915 | B | Inhibition of human BLK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 19. | ALA5251916 | B | Inhibition of human JAK3 preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature | |
| 20. | ALA5251917 | B | Inhibition of human TEC preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay | Homo sapiens | 1 | ALA5247657 | single protein format | Scientific Literature |
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