# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5252384 | B | Inhibition of human Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 26 | ALA5247677 | cell-based format | Scientific Literature | |
2. | ALA5252385 | B | Inhibition of mouse Nav1.7/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Mus musculus | 24 | ALA5247677 | cell-based format | Scientific Literature | |
3. | ALA5252387 | T | Inhibition of human Nav1.1/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 22 | ALA5247677 | cell-based format | Scientific Literature | |
4. | ALA5252388 | T | Inhibition of human Nav1.5/beta1/2 transfected in HEK293-A cells assessed as inhibition of channel current incubated for 5.5 mins by high-throughput electrophysiology system analysis | Homo sapiens | 22 | ALA5247677 | cell-based format | Scientific Literature | |
5. | ALA5252389 | U | Selectivity ratio of IC50 for human Nav1.1/beta1/2 transfected in HEK293-A cells to IC50 for human Nav1.7/beta1/2 transfected in HEK293-A cells | 4 | ALA5247677 | cell-based format | Scientific Literature | ||
6. | ALA5252390 | U | Selectivity ratio of IC50 for human Nav1.5/beta1/2 transfected in HEK293-A cells to IC50 for human Nav1.7/beta1/2 transfected in HEK293-A cells | 3 | ALA5247677 | cell-based format | Scientific Literature | ||
7. | ALA5252391 | T | Inhibition of hERG at 100 uM | Homo sapiens | 19 | ALA5247677 | assay format | Scientific Literature | |
8. | ALA5252392 | P | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 by HPLC/LC-MS analysis | 19 | ALA5247677 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5252393 | P | Aqueous thermodynamic solubility of the compound at pH 6.8 measured after 4 hrs by HPLC-UV analysis | 19 | ALA5247677 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA5252394 | A | Unbound fraction in mouse plasma | Mus musculus | 19 | ALA5247677 | cell-free format | Scientific Literature | |
11. | ALA5252413 | F | Analgesic activity against PSL-induced neuropathic pain mouse model assessed as reversal of thermal hyperalgesia at 3 mg/kg, po by plantar test | Mus musculus | 1 | ALA5247677 | organism-based format | Scientific Literature |