| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250788 | B | Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Leishmania infantum | 17 | ALA5247635 | assay format | Scientific Literature | |
| 2. | ALA5250789 | B | Disruption of HIS-FLAG-tagged recombinant Leishmania infantum TryR dimerization expressed in Escherichia coli Rossetta BL21 (DE3) cells incubated for 16 hrs by ELISA analysis | Leishmania infantum | 17 | ALA5247635 | cell-based format | Scientific Literature | |
| 3. | ALA5250797 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes assessed as reduction in parasite viability treated for 24 hrs by PI staining based flow cytometry | Leishmania infantum | 17 | ALA5247635 | organism-based format | Scientific Literature | |
| 4. | ALA5250798 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation treated for 24 hrs by crystal violet staining based analysis | Homo sapiens | 17 | ALA5247635 | cell-based format | Scientific Literature | |
| 5. | ALA5250799 | T | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes | 18 | ALA5247635 | assay format | Scientific Literature | ||
| 6. | ALA5250800 | F | Antileishmanial activity against GFP-expressing Leishmania infantum intracellular amastigotes infected in human THP-1 derived macrophage cells assessed as reduction in parasite viability measured for 72 hrs by resazurin/alamar blue fluorometric assay | Leishmania infantum | 14 | ALA5247635 | organism-based format | Scientific Literature | |
| 7. | ALA5250801 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis | Homo sapiens | 14 | ALA5247635 | cell-based format | Scientific Literature | |
| 8. | ALA5250802 | T | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for GFP-expressing Leishmania infantum intracellular amastigotes infected in human THP-1 derived macrophage cells | 14 | ALA5247635 | cell-based format | Scientific Literature |
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