| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5228491 | Binding | Inhibition of human recombinant LSD1/CoREST using ART(mK)QTARKSTGGKAPRKQLAGGK-biotin as substrate incubated for 15 mins | Homo sapiens | 6 | ALA5226336 | protein complex format | Scientific Literature | |
| 2. | ALA5228492 | ADME | Substrate activity at p-glycoprotein (unknown origin) expressed in pig LLC-PK1 cells coexpressing MDR1 assessed as efflux ratio at apparent permeability across basolateral to apical side to apparent permeability across apical to basolateral side at 1 uM measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 6 | ALA5226336 | cell-based format | Scientific Literature | |
| 3. | ALA5228499 | ADME | Drug metabolism in Sprague-Dawley rat brain assessed as fluorine-containing metabolite level in cortex at 10 mg/kg, iv measured after 1 to 4 hrs by HPLC-UV and LC/MS analysis | Rattus norvegicus | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 4. | ALA5228500 | Physicochemical | Retention time of the compound by HPLC method | 2 | ALA5226336 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA5228501 | ADME | Drug metabolism in cryopreserved human hepatocytes assessed as hydrolysis-mediated 6-fluoro-4-methylnicotinic acid formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Homo sapiens | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 6. | ALA5228502 | ADME | Drug metabolism in cryopreserved human hepatocytes assessed as N-acetylglucosamine conjugation-mediated metabolite formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Homo sapiens | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 7. | ALA5228503 | ADME | Drug metabolism in cryopreserved rat hepatocytes assessed as hydrolysis-mediated 6-fluoro-4-methylnicotinic acid formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Rattus norvegicus | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 8. | ALA5228504 | ADME | Drug metabolism in cryopreserved rat hepatocytes assessed as N-acetylglucosamine conjugation-mediated metabolite formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Rattus norvegicus | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 9. | ALA5228505 | ADME | Drug metabolism in cryopreserved monkey hepatocytes assessed as N-acetylglucosamine conjugation-mediated metabolite formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Macaca mulatta | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 10. | ALA5228506 | ADME | Drug metabolism in cryopreserved monkey hepatocytes assessed as hydrolysis-mediated 6-fluoro-4-methylnicotinic acid formation measured for 6 hrs by HPLC-UV and LC/MS analysis | Macaca mulatta | 1 | ALA5226336 | cell-based format | Scientific Literature | |
| 11. | ALA5228507 | Binding | Binding affinity to human recombinant LSD1 assessed as compound-FAD adduct formation at 1 mM incubated for 1 hr by LC-MS analysis | Homo sapiens | 1 | ALA5226336 | single protein format | Scientific Literature | |
| 12. | ALA5228508 | Binding | Inhibition of MAO-A (unknown origin) incubated for 10 mins followed by MAO substrate addition and measured after 60 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA5226336 | single protein format | Scientific Literature | |
| 13. | ALA5228509 | Binding | Inhibition of MAO-B (unknown origin) incubated for 10 mins followed by MAO substrate addition and measured after 60 mins by luciferin-based luminescence assay | Homo sapiens | 1 | ALA5226336 | single protein format | Scientific Literature | |
| 14. | ALA5228510 | ADME | Drug concentration in cynomolgus monkey plasma at 0.1 mg/kg, iv measured after 5 mins by LC-MS/MS analysis | Macaca fascicularis | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 15. | ALA5228511 | ADME | AUC(0 to 6 hrs) in cynomolgus monkey at 0.1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 16. | ALA5228512 | ADME | Half life in cynomolgus monkey at 0.1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 17. | ALA5228513 | ADME | Total clearance in cynomolgus monkey at 0.1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 18. | ALA5228514 | ADME | Volume of distribution at steady state in cynomolgus monkey at 0.1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 1 | ALA5226336 | organism-based format | Scientific Literature | |
| 19. | ALA5228515 | ADME | Unbound drug concentration in Sprague-Dawley rat plasma assessed as free fraction ratio | Rattus norvegicus | 1 | ALA5226336 | cell-free format | Scientific Literature | |
| 20. | ALA5228516 | ADME | Unbound drug concentration in cynomolgus monkey plasma assessed as free fraction ratio | Macaca fascicularis | 1 | ALA5226336 | cell-free format | Scientific Literature |
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