# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5239751 | B | Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cells incubated for 1 mins under shaking condition followed by 60 mins under dark condition by TR-FRET assay | Homo sapiens | 92 | ALA5236619 | cell-based format | Scientific Literature | |
2. | ALA5239752 | B | Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cells at 10 uM incubated for 1 mins under shaking condition followed by 60 mins under dark condition by TR-FRET assay relative to control | Homo sapiens | 78 | ALA5236619 | cell-based format | Scientific Literature | |
3. | ALA5239757 | B | Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifampicin-induced receptor activation incubated for 24 hrs by luminescence based analysis | Homo sapiens | 60 | ALA5236619 | cell-based format | Scientific Literature | |
4. | ALA5239758 | B | Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifampicin-induced receptor activation at 10 uM incubated for 24 hrs by luminescence based analysis relative to control | Homo sapiens | 60 | ALA5236619 | cell-based format | Scientific Literature | |
5. | ALA5239759 | B | Agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as transcriptional activation at 30 uM incubated for 24 hrs by luminescence based analysis | Homo sapiens | 64 | ALA5236619 | cell-based format | Scientific Literature | |
6. | ALA5239760 | B | Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in receptor basal activity at 30 uM incubated for 24 hrs by luminescence based analysis | Homo sapiens | 49 | ALA5236619 | cell-based format | Scientific Literature | |
7. | ALA5239762 | B | Effect on mouse PXR activity by luciferase reporter assay | Mus musculus | 2 | ALA5236619 | single protein format | Scientific Literature | |
8. | ALA5239763 | B | Effect on CAR activity in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter by luciferase reporter assay | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
9. | ALA5239764 | B | Effect on FXR activity in GeneBLAzer FXR-UAS-bla HEK 293T cells by fluorescence based analysis | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
10. | ALA5239765 | B | Effect on LXRalpha activity in GeneBLAzer LXRalpha-UAS-bla HEK 293T cells by fluorescence based analysis | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
11. | ALA5239766 | B | Effect on VDR activity in GeneBLAzer VDR-UAS-bla HEK 293T cells by fluorescence based analysis | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
12. | ALA5239767 | T | Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 24 to 72 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
13. | ALA5239768 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 to 72 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
14. | ALA5239769 | T | Cytotoxicity against human Hepa1-6 cells assessed as reduction in cell viability measured after 24 to 72 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature | |
15. | ALA5239770 | T | Cytotoxicity against human HepaRG cells assessed as reduction in cell viability measured after 24 to 72 hrs by celltiter-glo luminescent cell viability assay | Homo sapiens | 2 | ALA5236619 | cell-based format | Scientific Literature |