# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5259664 | F | Anti-hepatic fibrosis activity in human LX2 cells assessed as inhibition of COL1A1 promoter activity at 25 micromol/L by luciferase reporter assay relative to control | Homo sapiens | 56 | ALA5257100 | cell-based format | Scientific Literature | |
2. | ALA5259665 | F | Anti-hepatic fibrosis activity in human LX2 cells assessed as inhibition of TGF-beta1 induced COL1A1 mRNA expression at 3 micromol/L incubated for 24 hrs by qPCR analysis | Homo sapiens | 9 | ALA5257100 | cell-based format | Scientific Literature | |
3. | ALA5259676 | T | Cytotoxicity against human LX2 cells assessed as mortality rate at 1 to 30 uM incubated for 24 hrs by Sulfonyl Rhodamine B assay | Homo sapiens | 4 | ALA5257100 | cell-based format | Scientific Literature | |
4. | ALA5259677 | T | Cytotoxicity against mouse AML12 cells assessed as mortality rate at 1 to 30 uM incubated for 24 hrs by Sulfonyl Rhodamine B assay | Mus musculus | 4 | ALA5257100 | cell-based format | Scientific Literature | |
5. | ALA5259678 | B | Inhibition of JAK1/STAT1/STAT3 signaling pathway in human LX2 cells assessed as decrease in TGF-beta induced JAK1 phosphorylation level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA5257100 | cell-based format | Scientific Literature | |
6. | ALA5259679 | B | Inhibition of JAK1/STAT1/STAT3 signaling pathway in human LX2 cells assessed as decrease in TGF-beta induced STAT1 phosphorylation level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA5257100 | cell-based format | Scientific Literature | |
7. | ALA5259680 | B | Inhibition of JAK1/STAT1/STAT3 signaling pathway in human LX2 cells assessed as decrease in TGF-beta induced STAT3 phosphorylation level at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 4 | ALA5257100 | cell-based format | Scientific Literature |