| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256384 | B | Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as reduction of RB phosphorylation at Ser780 residue level at 1 to 8 uM incubated for 24 hrs by western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5256385 | B | Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK6 expression level at 1 to 8 uM incubated for 24 hrs by western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA5256386 | B | Inhibition of CDK4/CDK6 signaling pathway in human MDA-MB-231 cells assessed as inhibition of CDK4 expression level at 1 to 8 uM incubated for 24 hrs by western blot assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5256387 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 5. | ALA5256388 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 6. | ALA5256389 | F | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 7. | ALA5256390 | F | Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 8. | ALA5256391 | F | Antiproliferative activity against palbociclib-resistant human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA5256392 | F | Resistance factor, ratio of IC50 for palbociclib-resistant human MCF7 cells to IC50 for human MCF7 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA5256393 | B | Covalent inhibition of CDK4 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA5256394 | B | Covalent inhibition of CDK6 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA5256395 | B | Covalent inhibition of CDK9 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA5256396 | B | Covalent inhibition of CDK12 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA5256397 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as viable cells at 10 uM incubated for 24 hrs by annexin V-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 96.5%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA5256398 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 10 uM incubated for 24 hrs by annexin V-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 3.39%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA5256399 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as late apoptotic cells at 10 uM incubated for 24 hrs by annexin V-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.113%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA5256400 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as necrotic cells at 10 uM incubated for 24 hrs by annexin V-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.034%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA5256401 | F | Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells at G0/G1 phase at 10 uM incubated for 24 hrs by propidium iodide staining based assay (Rvb = 54.43%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA5256402 | F | Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells at G2/M phase at 10 uM incubated for 24 hrs by propidium iodide staining based assay (Rvb = 20.49%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA5256403 | F | Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells at S phase at 10 uM incubated for 24 hrs by propidium iodide staining based assay (Rvb = 25.09%) | Homo sapiens | 4 | cell-based format | Scientific Literature |
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