# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5246745 | B | Inhibition of N-terminal GST-fused human wild type LRRK2 using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by TR-FRET assay | Homo sapiens | 40 | ALA5244270 | single protein format | Scientific Literature | |
2. | ALA5246746 | B | Inhibition of N-terminal GST-fused human LRRK2 G2019S mutant using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by TR-FRET assay | Homo sapiens | 42 | ALA5244270 | single protein format | Scientific Literature | |
3. | ALA5246747 | B | Selectivity ratio of IC50 for inhibition of N-terminal GST-fused human wild type LRRK2 to IC50 for inhibition of N-terminal GST-fused human wild type LRRK2 G2019S mutant | Homo sapiens | 42 | ALA5244270 | assay format | Scientific Literature | |
4. | ALA5246748 | B | Inhibition of human wild type LRRK2 expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by HTRF analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
5. | ALA5246749 | B | Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pSer935 phosphorylation incubated for 2 hrs by HTRF analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
6. | ALA5246750 | B | Selectivity ratio of IC50 for inhibition of human wild type LRRK2 expressed in HEK293 cells to IC50 for inhibition of human LRRK2 G2019S mutant expressed in HEK293 | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
7. | ALA5246754 | B | Inhibition of human wild type LRRK2 expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation incubated for 2 hrs by MSD analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
8. | ALA5246755 | B | Inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation incubated for 2 hrs by MSD analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
9. | ALA5246756 | B | Selectivity ratio of IC50 for inhibition of human wild type LRRK2 expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation to IC50 for inhibition of human LRRK2 G2019S mutant expressed in HEK293 cells assessed as reduction in pS1292 phosphorylation | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
10. | ALA5246757 | B | Inhibition human wild type LRRK2 expressed in human HEK293 assessed as Rab10 substrate phosphorylation at Threonine 73 residue incubated for 2 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
11. | ALA5246758 | B | Inhibition human LRRK2 G2019S mutant expressed in human HEK293 assessed as Rab10 substrate phosphorylation at Threonine 73 residue incubated for 2 hrs by immunoblotting analysis | Homo sapiens | 8 | ALA5244270 | cell-based format | Scientific Literature | |
12. | ALA5246759 | B | Selectivity ratio of IC50 for inhibition human wild type LRRK2 expressed in human HEK293 assessed as Rab10 substrate phosphorylation at Threonine 73 residue to IC50 for inhibition of human LRRK2 G2019S mutant expressed in human HEK293 assessed as Rab10 substrate phosphorylation at Threonine 73 residue | Homo sapiens | 8 | ALA5244270 | assay format | Scientific Literature |