| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5248835 | F | Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA5247585 | cell-based format | Scientific Literature | |
| 2. | ALA5248836 | F | Antiproliferative activity against human NCI-H23 cells harboring KRAS G12C mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA5247585 | cell-based format | Scientific Literature | |
| 3. | ALA5248837 | F | Antiproliferative activity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA5247585 | cell-based format | Scientific Literature | |
| 4. | ALA5248838 | F | Antiproliferative activity against human NCI-H2228 cells harboring wild type KRAS assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA5247585 | cell-based format | Scientific Literature | |
| 5. | ALA5248839 | F | Selectivity index, ratio of IC50 for human A549 cells harboring KRAS G12S mutant to IC50 for human NCI-H358 cells harboring KRAS G12C mutant | Homo sapiens | 5 | ALA5247585 | assay format | Scientific Literature | |
| 6. | ALA5248840 | F | Selectivity index, ratio of IC50 for human NCI-H2228 cells harboring wild type KRAS to IC50 for human NCI-H358 cells harboring KRAS G12C mutant | Homo sapiens | 5 | ALA5247585 | assay format | Scientific Literature | |
| 7. | ALA5248841 | F | Selectivity index, ratio of IC50 for human A549 cells harboring KRAS G12S mutant to IC50 for human NCI-H23 cells harboring KRAS G12C mutant | Homo sapiens | 5 | ALA5247585 | assay format | Scientific Literature | |
| 8. | ALA5248842 | F | Selectivity index, ratio of IC50 for human NCI-H2228 cells harboring wild type KRAS to IC50 for human NCI-H23 cells harboring KRAS G12C mutant | Homo sapiens | 5 | ALA5247585 | assay format | Scientific Literature | |
| 9. | ALA5248843 | F | Antiproliferative activity against human SK-LU-1 cells harboring KRAS G12D mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5247585 | cell-based format | Scientific Literature | |
| 10. | ALA5248844 | F | Antiproliferative activity against human NCI-H441 cells harboring KRAS G12V mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5247585 | cell-based format | Scientific Literature | |
| 11. | ALA5248845 | T | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | Homo sapiens | 2 | ALA5247585 | cell-based format | Scientific Literature | |
| 12. | ALA5248846 | B | Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human NCI-H358 cells harboring KRAS G12C mutant | 1 | ALA5247585 | assay format | Scientific Literature | ||
| 13. | ALA5248847 | B | Covalent binding affinity to 6His tagged GDP bound human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli BL21 (DE3) cells at 200 uM incubated for 24 hrs by LC-MS /MS analysis | Homo sapiens | 3 | ALA5247585 | cell-based format | Scientific Literature | |
| 14. | ALA5248848 | B | Covalent binding affinity to 6his tagged GDP bound human wildtype KRAS expressed in Escherichia coli BL21 (DE3) cells at 200 uM incubated for 24 hrs by LC-MS/MS analysis | Homo sapiens | 3 | ALA5247585 | cell-based format | Scientific Literature | |
| 15. | ALA5248849 | B | Inhibition of 6His tagged Mant-GDP loaded human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of SOS1-mediated nucleotide exchange at 10 uM preincubated with compound for 1 hrs followed by addition of GTP and SOS1 protein and measured every 90 sec for 2 hrs by fluorescence based assay | Homo sapiens | 3 | ALA5247585 | cell-based format | Scientific Literature | |
| 16. | ALA5248850 | B | Inhibition of 6His tagged Mant-GDP loaded human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of GDP-catalyed nucleotide exchange at 10 uM preincubated with compound for 1 hrs followed by addition of GTP and EDTA and measured every 90 sec for 2 hrs by fluorescence based assay | Homo sapiens | 3 | ALA5247585 | cell-based format | Scientific Literature | |
| 17. | ALA5248851 | B | Inhibition of KRAS signaling in human NCI-H2228 cells harboring wildtype KRAS at 0.5 to 8 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5247585 | cell-based format | Scientific Literature | |
| 18. | ALA5248852 | B | Inhibition of KRAS signaling in human NCI-H358 cells harboring KRAS G12C mutant assessed as decrease in ERK phosphorylation level at 0.5 to 8 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5247585 | cell-based format | Scientific Literature | |
| 19. | ALA5248853 | B | Inhibition of KRAS signaling in human NCI-H358 cells harboring KRAS G12C mutant assessed as decrease in AKT phosphorylation level at 0.5 to 8 uM incubated for 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA5247585 | cell-based format | Scientific Literature | |
| 20. | ALA5248854 | F | Induction of apoptosis in human NCI-H358 cells assessed as fold change in cleaved caspase-3 level at 0.5 to 8 uM incubated for 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA5247585 | cell-based format | Scientific Literature |
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