# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5248912 | B | Inhibition of NTMT1 (unknown origin) using SPKRIAKRRS(CONH2) peptide as substrate assessed as SAH production incubated for 10 mins in the presence of SAM by HPLC analysis | Homo sapiens | 6 | single protein format | Scientific Literature | ||
2. | ALA5248913 | B | Potency index, ratio of DC541 IC50 to test compound IC50 for inhibition of NTMT1 (unknown origin) using SPKRIAKRRS(CONH2) peptide as substrate assessed as SAH production incubated for 10 mins in the presence of SAM by HPLC analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
3. | ALA5248916 | B | PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level at 50 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA5248917 | B | PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level at 50 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA5248930 | T | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability at 1 to 64 uM incubated for 24 hrs by WST-8 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA5248931 | T | Cytotoxicity against human HT-29 cells assessed as reduction in cell viability at 1 to 64 uM measured after 24 hrs by WST-8 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA5248932 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation incubated for 72 hrs by fluorescence based microplate reader analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA5248933 | F | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation at 1 to 64 uM incubated for 72 hrs by fluorescence based microplate reader analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA5248934 | F | Antiproliferative activity against NTMT1 knockout human HCT-116 cells at 1 to 64 uM incubated for 72 hrs by fluorescence based microplate reader analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA5248935 | F | Antiproliferative activity against human HCT-116 cells assessed as reduction in tumor spheroid growth at 64 uM measured after 12 days by imaging analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA5248937 | F | Antiproliferative activity against human HCT-116 cells cultured in PG-S assessed as decrease in cell number at 64 uM measured after 3 days by AO/PI staining based cell counter analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA5248945 | F | Upregulation of CALR in human HCT-116 cells assessed as fold change at 25 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |