| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239771 | B | Inhibition of FGFR4 (unknown origin) using TK as substrate incubated for 1 hr in presence of biotin/ATP by HTRF assay | Homo sapiens | 32 | single protein format | Scientific Literature | ||
| 2. | ALA5239772 | F | Cytotoxicity against human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA5239773 | B | Inhibition of FGFR4 V550L (unknown origin) using TK as substrate incubated for 1 hr in presence of biotin/ATP by HTRF assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 4. | ALA5239774 | B | Selectivity index, ratio of IC50 for inhibition of FGFR4 V550L (unknown origin) to IC50 for inhibition of wild type FGFR4 (unknown origin) | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 5. | ALA5239775 | F | Cytotoxicity against mouse BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA5239776 | F | Cytotoxicity against mouse BaF3 cells expressing wild type TEL-fused FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA5239777 | F | Cytotoxicity against mouse BaF3 cells expressing TEL-fused FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA5239778 | T | Selectivity index, ratio of IC50 for cytotoxicity against mouse BaF3 cells expressing TEL-fused FGFR4 V550L mutant to IC50 for cytotoxicity against mouse BaF3 cells expressing wild type TEL-fused FGFR4 | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA5239779 | A | Metabolic stability in human liver microsomes assessed as half life pretreated for 5 mins followed by NADPH addition and measured for 45 mins by LC/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 10. | ALA5239780 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured for 45 mins by LC/MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 11. | ALA5239781 | A | Metabolic stability in mouse liver microsomes assessed as half life pretreated for 5 mins followed by NADPH addition and measured for 45 mins by LC/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 12. | ALA5239782 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance pretreated for 5 mins followed by NADPH addition and measured for 45 mins by LC/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 13. | ALA5239783 | A | Metabolic stability in human assessed as intrinsic clearance | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 14. | ALA5239784 | A | Metabolic stability in mouse assessed as intrinsic clearance | Mus musculus | 5 | assay format | Scientific Literature | ||
| 15. | ALA5239785 | A | Half life in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5239786 | A | AUClast in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5239787 | A | AUCinfinity in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5239788 | A | MRTinfinity in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5239789 | A | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5239790 | A | Clearance in CD-1 mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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