| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5249658 | F | Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 2. | ALA5249659 | T | Cytotoxicity against human CCD 19Lu cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA5249660 | T | Selectivity index, ratio of IC50 for cytotoxicity against human CCD 19Lu cells to IC50 for cytotoxicity against human A549 cells | 10 | cell-based format | Scientific Literature | |||
| 4. | ALA5249661 | F | Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 5. | ALA5249662 | T | Cytotoxicity against human hTERT-HPNE cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 6. | ALA5249663 | T | Selectivity index, ratio of IC50 for cytotoxicity against human hTERT-HPNE cells to IC50 for cytotoxicity against human PANC-1 cells | 10 | cell-based format | Scientific Literature | |||
| 7. | ALA5249664 | F | Potency index, ratio of cisplatin IC50 for test compound IC50 for cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5249672 | F | Inhibition of DNA synthesis in human PANC-1 cells at IC50/4 to IC50 concentration incubated for 24 hrs by BrdU incorporation assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5249681 | F | Induction of apoptosis in human PANC-1 cells assessed as early apoptotic cells at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 0%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA5249682 | F | Induction of apoptosis in human PANC-1 cells assessed as late apoptotic cells at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 0.2%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA5249683 | F | Induction of apoptosis in human PANC-1 cells assessed as total cell viability at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 84.4%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA5249687 | F | Induction of apoptosis in human PANC-1 cells assessed as activation of caspase-3 by measuring caspase-3 positive cells at IC50 incubated for 24 hrs by flow cytometry analysis (Rvb = 1.8%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA5249688 | F | Induction of apoptosis in human PANC-1 cells assessed as activation of caspase-3 by measuring caspase-3 negative cells at IC50 incubated for 24 hrs by flow cytometry analysis (Rvb = 98.5 %) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 14. | ALA5249691 | F | Induction of mitochondrial membrane potential loss in human PANC-1 cells assessed as polarized cells at IC50 incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 92%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA5249692 | F | Induction of mitochondrial membrane potential loss in human PANC-1 cells assessed as depolarized cells at IC50 incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 5%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 16. | ALA5249713 | F | Induction of morphological changes in human PANC-1 cells assessed as cell shrinkage at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5249714 | F | Induction of morphological changes in human PANC-1 cells assessed as chromatin condensation at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5249715 | F | Induction of morphological changes in human PANC-1 cells assessed as formation of apoptotic bodies at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5249720 | B | Inhibition of cathepsin L (unknown origin) at 100 uM | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 20. | ALA5249724 | B | Inhibition of cathepsin D (unknown origin) at 100 uM | Homo sapiens | 4 | single protein format | Scientific Literature |
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