# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5249658 | Functional | Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | ALA5247607 | cell-based format | Scientific Literature | |
2. | ALA5249659 | Toxicity | Cytotoxicity against human CCD 19Lu cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | ALA5247607 | cell-based format | Scientific Literature | |
3. | ALA5249660 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human CCD 19Lu cells to IC50 for cytotoxicity against human A549 cells | 10 | ALA5247607 | cell-based format | Scientific Literature | ||
4. | ALA5249661 | Functional | Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | ALA5247607 | cell-based format | Scientific Literature | |
5. | ALA5249662 | Toxicity | Cytotoxicity against human hTERT-HPNE cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 10 | ALA5247607 | cell-based format | Scientific Literature | |
6. | ALA5249663 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human hTERT-HPNE cells to IC50 for cytotoxicity against human PANC-1 cells | 10 | ALA5247607 | cell-based format | Scientific Literature | ||
7. | ALA5249664 | Functional | Potency index, ratio of cisplatin IC50 for test compound IC50 for cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA5247607 | cell-based format | Scientific Literature | |
8. | ALA5249672 | Functional | Inhibition of DNA synthesis in human PANC-1 cells at IC50/4 to IC50 concentration incubated for 24 hrs by BrdU incorporation assay | Homo sapiens | 1 | ALA5247607 | cell-based format | Scientific Literature | |
9. | ALA5249681 | Functional | Induction of apoptosis in human PANC-1 cells assessed as early apoptotic cells at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 0%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
10. | ALA5249682 | Functional | Induction of apoptosis in human PANC-1 cells assessed as late apoptotic cells at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 0.2%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
11. | ALA5249683 | Functional | Induction of apoptosis in human PANC-1 cells assessed as total cell viability at IC50 incubated for 24 hrs by annexin V-FITC/PI staining based flow cytometry analysis (Rvb = 84.4%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
12. | ALA5249687 | Functional | Induction of apoptosis in human PANC-1 cells assessed as activation of caspase-3 by measuring caspase-3 positive cells at IC50 incubated for 24 hrs by flow cytometry analysis (Rvb = 1.8%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
13. | ALA5249688 | Functional | Induction of apoptosis in human PANC-1 cells assessed as activation of caspase-3 by measuring caspase-3 negative cells at IC50 incubated for 24 hrs by flow cytometry analysis (Rvb = 98.5 %) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
14. | ALA5249691 | Functional | Induction of mitochondrial membrane potential loss in human PANC-1 cells assessed as polarized cells at IC50 incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 92%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
15. | ALA5249692 | Functional | Induction of mitochondrial membrane potential loss in human PANC-1 cells assessed as depolarized cells at IC50 incubated for 24 hrs by JC-1 staining based flow cytometry assay (Rvb = 5%) | Homo sapiens | 5 | ALA5247607 | cell-based format | Scientific Literature | |
16. | ALA5249713 | Functional | Induction of morphological changes in human PANC-1 cells assessed as cell shrinkage at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA5247607 | cell-based format | Scientific Literature | |
17. | ALA5249714 | Functional | Induction of morphological changes in human PANC-1 cells assessed as chromatin condensation at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA5247607 | cell-based format | Scientific Literature | |
18. | ALA5249715 | Functional | Induction of morphological changes in human PANC-1 cells assessed as formation of apoptotic bodies at 13.58 uM incubated for 24 hrs by acridine orange/ethidium bromide staining based fluorescence microscopic analysis | Homo sapiens | 1 | ALA5247607 | cell-based format | Scientific Literature | |
19. | ALA5249720 | Binding | Inhibition of cathepsin L (unknown origin) at 100 uM | Homo sapiens | 8 | ALA5247607 | single protein format | Scientific Literature | |
20. | ALA5249724 | Binding | Inhibition of cathepsin D (unknown origin) at 100 uM | Homo sapiens | 4 | ALA5247607 | single protein format | Scientific Literature |