# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5237905 | B | Antagonist activity at alpha2a-adrenoceptor (unknown origin) assessed as reduction in adrenaline-induced response by measuring equilibrium binding constant | Homo sapiens | 12 | ALA5236573 | single protein format | Scientific Literature | |
2. | ALA5237906 | B | Antagonist activity at alpha2c-adrenoceptor (unknown origin) assessed as reduction in adrenaline-induced response by measuring equilibrium binding constant | Homo sapiens | 12 | ALA5236573 | single protein format | Scientific Literature | |
3. | ALA5237907 | B | Selectivity index, ratio of Kb for antagonist activity at alpha2a-adrenoceptor (unknown origin) to Kb for antagonist activity at alpha2c-adrenoceptor (unknown origin) | Homo sapiens | 12 | ALA5236573 | assay format | Scientific Literature | |
4. | ALA5237908 | A | Metabolic stability in human hepatocytes assessed as clearance per 10^6 cells at 1 uM | Homo sapiens | 12 | ALA5236573 | cell-based format | Scientific Literature | |
5. | ALA5237909 | A | Metabolic stability in rat hepatocytes assessed as clearance per 10^6 cells at 1 uM | Rattus norvegicus | 12 | ALA5236573 | cell-based format | Scientific Literature | |
6. | ALA5237910 | P | Lipophilicity, logD of the compound | 12 | ALA5236573 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5237911 | P | Solubility of the compound in pH 7.4 buffer | 12 | ALA5236573 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5237912 | A | Permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 12 | ALA5236573 | cell-based format | Scientific Literature | |
9. | ALA5237913 | A | Permeability across basolateral to apical side in human Caco-2 cells | Homo sapiens | 12 | ALA5236573 | cell-based format | Scientific Literature | |
10. | ALA5237914 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells | Homo sapiens | 12 | ALA5236573 | cell-based format | Scientific Literature |