#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA5232379	B	Agonist activity at human FXR expressed in human Huh-7 cells co-transfected with FXRE-Luc reporter plasmid assessed as receptor transactivation incubated for 16 hrs by luciferase reporter gene assay	Homo sapiens	29	ALA5230149	cell-based format	Scientific Literature
2.	ALA5232380	B	Agonist activity at human FXR expressed in human Huh-7 cells co-transfected with FXRE-Luc reporter plasmid assessed as receptor transactivation incubated for 16 hrs by luciferase reporter gene assay relative to OCA	Homo sapiens	29	ALA5230149	cell-based format	Scientific Literature
3.	ALA5232381	T	Agonist activity at human TGR5 expressed in HEK293 cells co-transfected with CRE-Luc reporter plasmid assessed as receptor transactivation incubated for 5.5 hrs by luciferase reporter gene assay	Homo sapiens	3	ALA5230149	cell-based format	Scientific Literature
4.	ALA5232382	T	Agonist activity at human TGR5 expressed in HEK293 cells co-transfected with CRE-Luc reporter plasmid assessed as receptor transactivation incubated for 5.5 hrs by luciferase reporter gene assay relative to OCA	Homo sapiens	3	ALA5230149	cell-based format	Scientific Literature
5.	ALA5232383	B	Agonist activity at FXR in C57BL/6J mouse hepatocytes assessed as upregulation of SHP mRNA expression incubated for 24 hrs by qRT-PCR analysis	Mus musculus	3	ALA5230149	cell-based format	Scientific Literature
6.	ALA5232384	B	Agonist activity at FXR in C57BL/6J mouse hepatocytes assessed as fold upregulation of SHP mRNA expression at 10 uM incubated for 24 hrs by qRT-PCR analysis relative to control	Mus musculus	3	ALA5230149	cell-based format	Scientific Literature
7.	ALA5232385	B	Agonist activity at FXR in C57BL/6J mouse hepatocytes assessed as upregulation of BSEP mRNA expression at 0.4 to 10 uM incubated for 24 hrs by qRT-PCR analysis	Mus musculus	3	ALA5230149	cell-based format	Scientific Literature
8.	ALA5232386	F	In vivo agonist activity at FXR in C57BL/6J mouse assessed as fold upregulation of SHP mRNA expression in liver at 10 mg/kg, po measured after 6 hrs by qRT-PCR analysis relative to control	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
9.	ALA5232388	F	In vivo agonist activity at FXR in C57BL/6J mouse assessed as downregulation of CYP7A1 mRNA expression in liver at 10 mg/kg, po measured after 6 hrs by qRT-PCR analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
10.	ALA5232390	F	In vivo agonist activity at FXR in C57BL/6J mouse assessed as downregulation of CYP8B1 mRNA expression in liver at 10 mg/kg, po measured after 6 hrs by qRT-PCR analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
11.	ALA5232392	F	In vivo agonist activity at FXR in C57BL/6J mouse assessed as fold upregulation of SHP mRNA expression in ileum at 10 mg/kg, po measured after 6 hrs by qRT-PCR analysis relative to control	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
12.	ALA5232394	F	In vivo agonist activity at FXR in C57BL/6J mouse assessed as fold upregulation of FGF15 mRNA expression in ileum at 10 mg/kg, po measured after 6 hrs by qRT-PCR analysis relative to control	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
13.	ALA5232396	A	Drug uptake in ICR mouse liver at 15 mg/kg, po measured after 1.5 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
14.	ALA5232397	A	Drug uptake in ICR mouse liver at 15 mg/kg, po measured after 4 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
15.	ALA5232398	A	Drug uptake in ICR mouse liver at 15 mg/kg, po measured after 8 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
16.	ALA5232399	A	Plasma concentration in ICR mouse at 15 mg/kg, po measured after 1.5 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
17.	ALA5232400	A	Plasma concentration in ICR mouse at 15 mg/kg, po measured after 4 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
18.	ALA5232401	A	Plasma concentration in ICR mouse at 15 mg/kg, po measured after 8 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
19.	ALA5232402	A	Ratio of drug uptake in ICR mouse liver to plasma at 15 mg/kg, po measured after 1.5 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature
20.	ALA5232403	A	Ratio of drug uptake in ICR mouse liver to plasma at 15 mg/kg, po measured after 4 hrs by LC-MS/MS analysis	Mus musculus	2	ALA5230149	organism-based format	Scientific Literature