| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250899 | F | Anti-NASH activity in high-fat diet and CCl4-induced nonalcoholic steatohepatitis C57BL/6J mouse assessed as reduction in col-1A1 gene expression in liver at 3 to 10 mg/kg, po once daily and measured after 48 hrs by sirius red staining based assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5250900 | B | Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 3. | ALA5250901 | B | Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 4. | ALA5250902 | U | Fold of selectivity, ratio of compound EC50/T3 EC50 for THRalpha to ratio of compound EC50/T3 EC50 for THRbeta | 20 | assay format | Scientific Literature | |||
| 5. | ALA5250903 | A | Half life in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA5250904 | A | Tmax in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA5250905 | A | Cmax in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA5250906 | A | AUClast in ICR mouse at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA5250907 | A | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 10. | ALA5250908 | A | Metabolic stability in rat liver microsomes assessed as half life | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 11. | ALA5250909 | A | Metabolic stability in mouse liver microsomes assessed as half life | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 12. | ALA5250910 | A | Metabolic stability in dog liver microsomes assessed as half life | Canis lupus familiaris | 1 | microsome format | Scientific Literature | ||
| 13. | ALA5250911 | A | Metabolic stability in monkey liver microsomes assessed as half life | Macaca mulatta | 1 | microsome format | Scientific Literature | ||
| 14. | ALA5250912 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 15. | ALA5250913 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 16. | ALA5250914 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 17. | ALA5250915 | A | Metabolic stability in dog liver microsomes assessed as intrinsic clearance | Canis lupus familiaris | 1 | microsome format | Scientific Literature | ||
| 18. | ALA5250916 | A | Metabolic stability in monkey liver microsomes assessed as intrinsic clearance | Macaca mulatta | 1 | microsome format | Scientific Literature | ||
| 19. | ALA5250917 | A | Half life in ICR mouse serum at 10 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA5250918 | A | Tmax in ICR mouse serum at 10 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature |
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