| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5223843 | B | Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay | Homo sapiens | 73 | cell-based format | Scientific Literature | ||
| 2. | ALA5223844 | B | Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene luminescence assay relative to control | Homo sapiens | 68 | cell-based format | Scientific Literature | ||
| 3. | ALA5223845 | A | Drug metabolism in rat liver microsomes incubated for 30 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 26 | microsome format | Scientific Literature | ||
| 4. | ALA5223846 | A | Drug metabolism in human liver microsomes incubated for 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 26 | microsome format | Scientific Literature | ||
| 5. | ALA5223847 | T | Inhibition of hERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 6. | ALA5223848 | T | Inhibition of hERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assay relative to control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 7. | ALA5223849 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 mins in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 8. | ALA5223850 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 12 mins in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 9. | ALA5223851 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH regenerating system measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 13 | microsome format | Scientific Literature | ||
| 10. | ALA5223852 | A | Oral bioavailability in Wistar rat at 3 mg/kg measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 11. | ALA5223853 | A | Cmax in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 12. | ALA5223854 | A | AUC in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 13. | ALA5223855 | A | Elimination half life in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 14. | ALA5223856 | A | Volume of distribution at steady state in Wistar rat at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 15. | ALA5223857 | A | Clearance in Wistar rat at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 16. | ALA5223858 | A | Ratio of drug level in Wistar rat brain to plasma at 10 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Rattus norvegicus | 19 | organism-based format | Scientific Literature | ||
| 17. | ALA5223867 | F | Pro-cognitive activity in Wistar rat assessed as attenuation of long-term memory deficit by measuring increase in exploration time for novel object at 1 to 3 mg/kg, po by object recognition test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5223869 | F | Pro-cognitive activity in Wistar rat assessed as reduction in scopalamine-induced amnesia at 1 to 10 mg/kg, po by radial arm maze test | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 19. | ALA5223870 | F | Pro-cognitive activity in Wistar rat assessed as attenuation of long-term memory deficit by measuring increase in exploration time for novel object at 0.03 to 0.1 mg/kg, po by object recognition test | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5223871 | F | Pro-cognitive activity in Wistar rat assessed as attenuation of long-term memory deficit by measuring increase in object recognition index at 3 mg/kg, po by object recognition test | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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