| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5251567 | A | Metabolic stability in dog liver microsomes assessed as intrinsic clearance at 1 uM and measured upto 15 mins in presence of NADPH regenerating system by LC-MS/MS analysis | Canis lupus familiaris | 3 | microsome format | Scientific Literature | ||
| 2. | ALA5251568 | A | Metabolic stability in human hepatocytes assessed as intrinsic clearance per 10^6 cells at 1 uM by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA5251569 | A | Metabolic stability in rat hepatocytes assessed as intrinsic clearance per 10^6 cells at 1 uM by LC-MS/MS analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA5251570 | A | Metabolic stability in dog hepatocytes assessed as intrinsic clearance per 10^6 cells at 1 uM by LC-MS/MS analysis | Canis lupus familiaris | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5251571 | A | Total clearance in Wistar rat plasma at 0.5 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA5251572 | A | Unbound clearance in Wistar rat plasma at 0.5 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA5251573 | A | Total clearance in Beagle dog plasma at 1 mg/kg, iv | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA5251574 | A | Unbound clearance in Beagle dog plasma at 1 mg/kg, iv | Canis lupus familiaris | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA5251576 | A | Drug excretion in urine of Wistar rat assessed as unchanged drug at 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA5251578 | B | Antagonist activity at mouse CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary mouse T cells assessed as inhibition of CXCLI1 mediated cell migration incubated for 45 mins by Boyden chamber assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5251579 | B | Antagonist activity at human CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary human T cells assessed as inhibition of CXCLI1 mediated cell migration incubated for 45 mins by Boyden chamber assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5251580 | B | Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL9 induced calcium flux by FLIPR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5251581 | B | Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5251582 | B | Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5251583 | B | Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5251584 | B | Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5251585 | B | Antagonist activity at rat CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5251586 | B | Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5251587 | B | Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR method | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5251588 | B | Binding affinity to human CXCR3 expressed in CHO-K1 cell membrane assessed as dissociation constant using tritium-labeled ligand by FLIPR assay | Homo sapiens | 1 | cell membrane format | Scientific Literature |
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