| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250036 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells at 5 to 20 uM pretreated with compound for 24 hrs followed by hydrogen peroxide addition for 2 hrs by MTT assay | Rattus norvegicus | 3 | ALA5247615 | cell-based format | Scientific Literature | |
| 2. | ALA5250038 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as increase in cell viability at 5 to 20 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 2 | ALA5247615 | cell-based format | Scientific Literature | |
| 3. | ALA5250039 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as increase in cell viability at 5 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 2 | ALA5247615 | cell-based format | Scientific Literature | |
| 4. | ALA5250040 | Toxicity | Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability upto 100 uM measured after 24 hrs by MTT assay relative to control | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 5. | ALA5250041 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as reduction in loss of cell membrane integrity by measuring LDH level at 5 uM pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs relative to control | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 6. | ALA5250042 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as reduction in loss of cell membrane integrity by measuring LDH level at 10 uM pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs relative to control | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 7. | ALA5250043 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as reduction in loss of cell membrane integrity by measuring LDH level at 20 uM pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs relative to control | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 8. | ALA5250044 | Functional | Cardioprotective activity against hydrogen peroxide induced cell injury in rat H9c2 cells assessed as reversal of abnormal cell morphology pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 9. | ALA5250045 | Functional | Inhibition of autophagy in hydrogen peroxide induced rat H9c2 cells assessed as down regulation of Beclin-2 mRNA level at 5 to 20 uM pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 10. | ALA5250046 | Functional | Inhibition of autophagy in hydrogen peroxide induced rat H9c2 cells assessed as down regulation of p62 mRNA level at 5 to 20 uM pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 11. | ALA5250047 | Functional | Antiinflammatory activity in hydrogen peroxide induced rat H9c2 cells assessed as reversal of increase in NLRP-3 mRNA expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 12. | ALA5250048 | Functional | Antiinflammatory activity in hydrogen peroxide induced rat H9c2 cells assessed as reversal of increase in IL-1beta mRNA expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 13. | ALA5250049 | Functional | Antiinflammatory activity in hydrogen peroxide induced rat H9c2 cells assessed as reversal of increase in IL-18 mRNA expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 14. | ALA5250050 | Functional | Antioxidant activity in hydrogen peroxide induced rat H9c2 cells assessed as increase in Nrf2 expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 15. | ALA5250051 | Functional | Antioxidant activity in hydrogen peroxide induced rat H9c2 cells assessed as increase in HO-1 expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 16. | ALA5250052 | Functional | Antioxidant activity in hydrogen peroxide induced rat H9c2 cells assessed as increase in SOD expression pretreated with compound for 24 hrs followed by treatment with hydrogen peroxide for 2 hrs | Rattus norvegicus | 1 | ALA5247615 | cell-based format | Scientific Literature | |
| 17. | ALA5250053 | Functional | Cardioprotective activity in myocardial ischemia/reperfusion induced Sprague-Dawley rat injury model assessed as decrease in ST-segment elevation at 5 to 20 mg/kg, ip administered once a day for 2 weeks measured by electrocardiogram | Rattus norvegicus | 1 | ALA5247615 | organism-based format | Scientific Literature | |
| 18. | ALA5250054 | Functional | Cardioprotective activity in myocardial ischemia/reperfusion induced Sprague-Dawley rat injury model assessed as reduction in cardiac infarct size at 10 mg/kg, ip administered once a day for 2 weeks measured by Evans blue staining analysis (Rvb = 46.8%) | Rattus norvegicus | 1 | ALA5247615 | organism-based format | Scientific Literature | |
| 19. | ALA5250055 | Functional | Cardioprotective activity in myocardial ischemia/reperfusion induced Sprague-Dawley rat injury model assessed as reduction in heart cardiac infarct size at 20 mg/kg, ip administered once a day for 2 weeks measured by Evans blue staining analysis (Rvb = 46.8%) | Rattus norvegicus | 1 | ALA5247615 | organism-based format | Scientific Literature | |
| 20. | ALA5250056 | Functional | Cardioprotective activity in myocardial ischemia/reperfusion induced ip dosed Sprague-Dawley rat injury model assessed as increase in heart AST level administered once a day for 2 weeks | Rattus norvegicus | 1 | ALA5247615 | organism-based format | Scientific Literature |
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