# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5250788 | B | Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Leishmania infantum | 17 | ALA5247635 | assay format | Scientific Literature | |
2. | ALA5250789 | B | Disruption of HIS-FLAG-tagged recombinant Leishmania infantum TryR dimerization expressed in Escherichia coli Rossetta BL21 (DE3) cells incubated for 16 hrs by ELISA analysis | Leishmania infantum | 17 | ALA5247635 | cell-based format | Scientific Literature | |
3. | ALA5250797 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes assessed as reduction in parasite viability treated for 24 hrs by PI staining based flow cytometry | Leishmania infantum | 17 | ALA5247635 | organism-based format | Scientific Literature | |
4. | ALA5250798 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation treated for 24 hrs by crystal violet staining based analysis | Homo sapiens | 17 | ALA5247635 | cell-based format | Scientific Literature | |
5. | ALA5250799 | T | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes | 18 | ALA5247635 | assay format | Scientific Literature |