# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5239614 | Binding | Inhibition of GST-tagged bacterial beta-lactamase NMD-1 expressed in Escherichia coli BL21(DE3) using CCF2-FA as substrate by fluorescence assay | Bacteria | 21 | ALA5236617 | assay format | Scientific Literature | |
2. | ALA5239615 | Binding | Inhibition of GST-tagged bacterial beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) using CCF2-FA as substrate by fluorescence assay | Bacteria | 21 | ALA5236617 | assay format | Scientific Literature | |
3. | ALA5239616 | Binding | Inhibition of GST-tagged bacterial beta-lactamase VIM-1 expressed in Escherichia coli BL21(DE3) using CCF2-FA as substrate by fluorescence assay | Bacteria | 21 | ALA5236617 | assay format | Scientific Literature | |
4. | ALA5239617 | Functional | Potentiation of imipenem-induced antibacterial activity against NDM-1 expressing Escherichia coli assessed as imipenem MIC incubated for 22 to 24 hrs (Rvb = 32 ug/ml) | Escherichia coli | 10 | ALA5236617 | organism-based format | Scientific Literature | |
5. | ALA5239618 | Functional | Potentiation of imipenem-induced antibacterial activity against IMP-1 expressing Serratia marcescens assessed as imipenem MIC incubated for 22 to 24 hrs (Rvb = 16 ug/ml) | Serratia marcescens | 10 | ALA5236617 | organism-based format | Scientific Literature | |
6. | ALA5239619 | Functional | Potentiation of imipenem-induced antibacterial activity against VIM-1 expressing Klebsiella pneumoniae assessed as imipenem MIC incubated for 22 to 24 hrs (Rvb = 16 ug/ml) | Klebsiella pneumoniae | 10 | ALA5236617 | organism-based format | Scientific Literature | |
7. | ALA5239620 | Unassigned | Selectivity ratio of MITC50 for NDM-1 expressing Escherichia coli to IC50 for GST-tagged bacterial beta-lactamase NMD-1 | 10 | ALA5236617 | assay format | Scientific Literature | ||
8. | ALA5239621 | Unassigned | Selectivity ratio of MITC50 for IMP-1 expressing Serratia marcescens to IC50 for GST-tagged bacterial beta-lactamase IMP-1 | 10 | ALA5236617 | assay format | Scientific Literature | ||
9. | ALA5239622 | Unassigned | Selectivity ratio of MITC50 for VIM-1 expressing Klebsiella pneumoniae to IC50 for GST-tagged bacterial beta-lactamase VIM-1 | 9 | ALA5236617 | assay format | Scientific Literature | ||
10. | ALA5239623 | Binding | Displacement of MK499 from human ERG | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
11. | ALA5239624 | Binding | Inhibition of Nav1.5 (unknown origin) | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
12. | ALA5239625 | Binding | Inhibition of Cav1.5 (unknown origin) | Homo sapiens | 1 | ALA5236617 | assay format | Scientific Literature | |
13. | ALA5239626 | ADME | Reversible inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
14. | ALA5239627 | ADME | Reversible inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
15. | ALA5239628 | ADME | Reversible inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
16. | ALA5239629 | ADME | Selectivity ratio of time dependent inhibition of CYP3A4 (unknown origin) in presence of NADPH to time dependent inhibition of CYP3A4 (unknown origin) in absence of NADPH | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
17. | ALA5239630 | Binding | Inhibition of human PXR | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
18. | ALA5239631 | Binding | Inhibition of human PXR at 30 uM relative to control | Homo sapiens | 1 | ALA5236617 | single protein format | Scientific Literature | |
19. | ALA5239632 | ADME | Plasma protein binding in C57BL/6 mouse assessed as unbound fraction | Mus musculus | 1 | ALA5236617 | cell-free format | Scientific Literature | |
20. | ALA5239633 | ADME | Plasma protein binding in Wistar Han rat assessed as unbound fraction | Rattus norvegicus | 1 | ALA5236617 | cell-free format | Scientific Literature |