# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5250387 | F | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 2 days by CCK8 assay | Homo sapiens | 36 | ALA5247625 | cell-based format | Scientific Literature | |
2. | ALA5250390 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 5 nM by Western blotting analysis | Homo sapiens | 19 | ALA5247625 | cell-based format | Scientific Literature | |
3. | ALA5250391 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 19 | ALA5247625 | cell-based format | Scientific Literature | |
4. | ALA5250392 | A | Apparent permeability in human Caco-2 cells incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
5. | ALA5250393 | B | Binding affinity to recombinant ABL (unknown origin) | Homo sapiens | 1 | ALA5247625 | single protein format | Scientific Literature | |
6. | ALA5250394 | F | Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 2 days by CCK8 assay | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
7. | ALA5250395 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | ALA5247625 | cell-based format | Scientific Literature | |
8. | ALA5250396 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in c-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | ALA5247625 | cell-based format | Scientific Literature | |
9. | ALA5250397 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis relative to control | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
10. | ALA5250398 | B | Inhibition of BCR-ABL phosphorylation at Tyr245 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | ALA5247625 | cell-based format | Scientific Literature | |
11. | ALA5250399 | B | Inhibition of STAT5 phosphorylation at Tyr694 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | ALA5247625 | cell-based format | Scientific Literature | |
12. | ALA5250400 | B | Inhibition of CRKL phosphorylation at Tyr207 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | ALA5247625 | cell-based format | Scientific Literature | |
13. | ALA5250401 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
14. | ALA5250402 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as BCR-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
15. | ALA5250403 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as c-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
16. | ALA5250404 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
17. | ALA5250405 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
18. | ALA5250406 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with MLN4924 for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
19. | ALA5250407 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature | |
20. | ALA5250408 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | ALA5247625 | cell-based format | Scientific Literature |