| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5250387 | F | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 2 days by CCK8 assay | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 2. | ALA5250390 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 5 nM by Western blotting analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 3. | ALA5250391 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 4. | ALA5250392 | A | Apparent permeability in human Caco-2 cells incubated for 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5250393 | B | Binding affinity to recombinant ABL (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA5250394 | F | Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 2 days by CCK8 assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5250395 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5250396 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in c-ABL degradation incubated for 16 hrs by Western blotting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA5250397 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as increase in BCR-ABL degradation at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5250398 | B | Inhibition of BCR-ABL phosphorylation at Tyr245 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA5250399 | B | Inhibition of STAT5 phosphorylation at Tyr694 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA5250400 | B | Inhibition of CRKL phosphorylation at Tyr207 residue in human K562 cells at 0.3 to 100 nM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA5250401 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5250402 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as BCR-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5250403 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as c-ABL turnover rate in presence of cycloheximide by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5250404 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5250405 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5250406 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of BCR-ABL degradation at 100 nM pretreated with MLN4924 for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5250407 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with lenalidomide for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5250408 | B | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as induction of c-ABL degradation at 100 nM pretreated with asciminib for 2 hrs followed by compound addition measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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