| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5228361 | B | Inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction incubated for 1 hr by Alphascreen assay | Homo sapiens | 43 | ALA5226326 | assay format | Scientific Literature | |
| 2. | ALA5228362 | B | Inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction assessed as inhibition constant incubated for 1 hr by Alphascreen assay | Homo sapiens | 43 | ALA5226326 | assay format | Scientific Literature | |
| 3. | ALA5228366 | B | Inhibition of full length beta-catenin D145A mutant/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction in human SW480 cells incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 4. | ALA5228367 | B | Inhibition of full length beta-catenin E155A mutant/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction in human SW480 cells incubated for 1 hr by Alphascreen assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 5. | ALA5228368 | B | Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 2 hr by Alphascreen assay | Homo sapiens | 1 | ALA5226326 | assay format | Scientific Literature | |
| 6. | ALA5228369 | B | Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction incubated for 2 hr by fluorescence anisotropy binding assay | Homo sapiens | 1 | ALA5226326 | assay format | Scientific Literature | |
| 7. | ALA5228370 | B | Inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction assessed as inhibition constant incubated for 2 hr by Alphascreen assay | Homo sapiens | 1 | ALA5226326 | assay format | Scientific Literature | |
| 8. | ALA5228371 | B | Selectivity ratio, ratio of Ki for inhibition of full length beta-catenin (1 to 781 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human BCL9 HD2 (350 to 375 residues) protein-protein interaction to Ki for inhibition of full length beta-catenin (1 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)/N-terminal biotinylated human E-cadherin (824 to 877 residues) protein-protein interaction | Homo sapiens | 1 | ALA5226326 | assay format | Scientific Literature | |
| 9. | ALA5228372 | B | Inhibition of beta-catenin/BCL9 protein-protein interaction in human HCT-116 cells at 1 to 12.5 uM incubated for 24 hr by Co-immunoprecipitation assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 10. | ALA5228373 | B | Inhibition of beta-catenin/E-cadherin protein-protein interaction in human HCT-116 cells at 1 to 12.5 uM incubated for 24 hr by Co-immunoprecipitation assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 11. | ALA5228374 | B | Inhibition of Wnt/beta-catenin transactivation signalling in human SW480 cells transfected with renilla luciferase and TOPFlash reporter gene incubated for 24 hrs by dual-luciferase assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 12. | ALA5228375 | B | Inhibition of Wnt/beta-catenin transactivation signalling in human SW480 cells transfected with renilla luciferase and FOPFlash reporter gene at 1.56 uM incubated for 24 hrs by dual-luciferase assay (Rvb = 100%) | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 13. | ALA5228376 | B | Inhibition of Wnt/beta-catenin transactivation signalling in human SW480 cells transfected with renilla luciferase and FOPFlash reporter gene at 3.125 uM incubated for 24 hrs by dual-luciferase assay (Rvb = 100%) | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 14. | ALA5228377 | B | Inhibition of Wnt/beta-catenin transactivation signalling in human SW480 cells transfected with renilla luciferase and FOPFlash reporter gene at 6.25 uM incubated for 24 hrs by dual-luciferase assay (Rvb = 100%) | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 15. | ALA5228378 | B | Inhibition of Wnt/beta-catenin transactivation signalling in human HEK293 cells transfected with TOPFlash reporter gene incubated for 24 hrs by TOPFlash luciferase assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 16. | ALA5228379 | B | Inhibition of Wnt/beta-catenin D145A/E155A mutant transactivation signalling in human HEK293 cells transfected with TOPFlash reporter gene incubated for 24 hrs by TOPFlash luciferase assay | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 17. | ALA5228380 | B | Selectivity ratio, ratio of IC50 for inhibition of Wnt/beta-catenin transactivation signalling in human HEK293 cells transfected with TOPFlash reporter gene to IC50 for inhibition of Wnt/beta-catenin D145A/E155A mutant transactivation signalling in human HEK293 cells transfected with TOPFlash reporter gene | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 18. | ALA5228381 | A | Drug uptake in human MDA-MB-231 cells at 2 uM incubated at 37 degree C measured after 6 hrs by HPLC analysis | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 19. | ALA5228382 | B | Inhibition of Wnt/beta-catenin signaling pathway in human SW480 cells assessed as reduction in Axin2 level at 12.5 uM incubated for 24 hrs by qRT-PCR analysis (Rvb = 100%) | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature | |
| 20. | ALA5228383 | B | Inhibition of Wnt/beta-catenin signaling pathway in human SW480 cells assessed as reduction in BCL9L level at 12.5 uM incubated for 24 hrs by qRT-PCR analysis (Rvb = 100%) | Homo sapiens | 1 | ALA5226326 | cell-based format | Scientific Literature |
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