# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5258273 | Functional | Induction of ROS generation in Leishmania amazonensis promastigotes assessed as reduction in endogenous GSH level at 4.3 to 29.2 uM incubated for 3 hrs by absorbance based analysis | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
2. | ALA5258275 | Functional | Antileishmanial activity against Leishmania amazonensis promastigotes infected in BALB/c mouse assessed as reduction of parasite burden at 1 mg/kg per day administered once a week for 4 weeks measured at 10 week by limit dilution assay | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
3. | ALA5258278 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 4.3 uM measured after 1 day by dye exclusion method (Rvb = 14.5 +/- 3.5) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
4. | ALA5258279 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 4.3 uM measured after 2 day by dye exclusion method (Rvb = 11.6 +/- 3.3) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
5. | ALA5258280 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 14.3 uM measured after 1 day by dye exclusion method (Rvb = 14.5 +/- 3.5) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
6. | ALA5258281 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 14.3 uM measured after 2 day by dye exclusion method (Rvb = 11.6 +/- 3.3) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
7. | ALA5258282 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 29.2 uM measured after 1 day by dye exclusion method (Rvb = 14.5 +/- 3.5) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
8. | ALA5258283 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/VE/84/MEL promastigotes assessed as parasite mortality at 29.2 uM measured after 2 day by dye exclusion method (Rvb = 11.6 +/- 3.3) | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
9. | ALA5258284 | Functional | Induction of ROS generation in Leishmania amazonensis promastigotes at 4.3 to 29.2 uM incubated for 48 hrs followed by probe addition measured after 1 hr by H2DCFDA probe based fluorometry analysis | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
10. | ALA5258285 | Functional | Induction of ROS generation in Leishmania amazonensis promastigotes assessed as reduction in mitochondrial activity at 4.3 to 29.2 uM incubated for 48 hrs by MTT assay | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
11. | ALA5258286 | Functional | Antileishmanial activity against Leishmania amazonensis promastigotes infected in BALB/c mouse assessed as reduction in RHLF lesion size at 1 mg/kg per day administered once a week for 4 weeks measured at 10 week | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
12. | ALA5258289 | Functional | Antileishmanial activity against Leishmania amazonensis promastigotes infected in BALB/c mouse assessed as reduction of splenic index at 1 mg/kg per day administered once a week for 4 weeks measured at 10 week | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
13. | ALA5258291 | Functional | Antileishmanial activity against Leishmania amazonensis promastigotes infected in BALB/c mouse assessed as reduction of IgG level at 1 mg/kg per day administered once a week for 4 weeks measured at 10 week by ELISA assay | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature | |
14. | ALA5258292 | Functional | Antileishmanial activity against Leishmania amazonensis promastigotes infected in BALB/c mouse assessed as reduction of IgG1 level at 1 mg/kg per day administered once a week for 4 weeks measured at 10 week by ELISA assay | Leishmania amazonensis | 2 | ALA5257045 | organism-based format | Scientific Literature |