| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256717 | B | Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 2. | ALA5256718 | A | Metabolic stability in rat liver microsomes assessed as intrinsic clearance preincubation with compound followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Rattus norvegicus | 17 | microsome format | Scientific Literature | ||
| 3. | ALA5256719 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance preincubation with compound followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 4. | ALA5256720 | A | Apparent permeability of compound across apical to basolateral side in dog MDCK-MDR1 cells incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA5256721 | A | Substrate activity at P-gp in dog MDCK-MDR1 cells assessed as efflux ratio incubated for 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA5256722 | P | Kinetic solubility of compound at pH 7.4 at 1 to 100 uM incubated for 2 hrs by UV-visible spectroscopy analysis | 17 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA5256723 | P | Octanol-water partition coefficient, log D of the compound by chromatographic method | 17 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5256724 | P | Lipophilicity, logP of the compound by shake flask assay | 3 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!