# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5264760 | Binding | Inhibition of PDE3A (unknown origin) by 3H-cAMP scintillation proximity assay | Homo sapiens | 1 | ALA5260844 | single protein format | Scientific Literature | |
2. | ALA5264761 | Binding | Inhibition of PDE3B (unknown origin) by 3H-cAMP scintillation proximity assay | Homo sapiens | 1 | ALA5260844 | single protein format | Scientific Literature | |
3. | ALA5264762 | Binding | Inhibition of PDE4B (unknown origin) by 3H-cAMP scintillation proximity assay | Homo sapiens | 1 | ALA5260844 | single protein format | Scientific Literature | |
4. | ALA5264763 | Binding | Inhibition of PDE5 (unknown origin) by 3H-cAMP scintillation proximity assay | Homo sapiens | 1 | ALA5260844 | single protein format | Scientific Literature | |
5. | ALA5264764 | Binding | Inhibition of PDE6 (unknown origin) by 3H-cAMP scintillation proximity assay | Homo sapiens | 1 | ALA5260844 | protein format | Scientific Literature | |
6. | ALA5264765 | Toxicity | Toxicity in NMRI nude mouse assessed as tolerance at 10 mg/kg, po administered twice daily for 44 days | Mus musculus | 1 | ALA5260844 | organism-based format | Scientific Literature | |
7. | ALA5264766 | Toxicity | Toxicity in NMRI nude mouse assessed as tolerance at 20 mg/kg, po administered twice daily for 44 days | Mus musculus | 1 | ALA5260844 | organism-based format | Scientific Literature | |
8. | ALA5264767 | Toxicity | Toxicity in NMRI nude mouse assessed as tolerance at 50 mg/kg, po administered once daily for 44 days | Mus musculus | 1 | ALA5260844 | organism-based format | Scientific Literature | |
9. | ALA5264768 | Functional | Antitumor activity against human SK-MEL3 cells xenografted in NMRI nude mouse assessed as tumor weight by measuring tumor to control ratio at 50 mg/kg, po administered once daily for 44 days | Homo sapiens | 1 | ALA5260844 | organism-based format | Scientific Literature | |
10. | ALA5264769 | Functional | Antitumor activity against human SK-MEL3 cells xenografted in NMRI nude mouse assessed as tumor growth inhibition by measuring tumor to control ratio at 50 mg/kg, po administered once daily for 44 days | Homo sapiens | 1 | ALA5260844 | organism-based format | Scientific Literature | |
11. | ALA5264770 | Functional | Antitumor activity against human SK-MEL3 cells xenografted in NMRI nude mouse assessed as tumor growth inhibition at 50 mg/kg, po administered once daily for 44 days | Homo sapiens | 1 | ALA5260844 | organism-based format | Scientific Literature | |
12. | ALA5264771 | Functional | Antitumor activity against human SK-MEL3 cells xenografted in NMRI nude mouse assessed as tumor growth inhibition at 20 mg/kg, po administered twice daily for 44 days | Homo sapiens | 1 | ALA5260844 | organism-based format | Scientific Literature | |
13. | ALA5264772 | Functional | Antitumor activity against human SK-MEL3 cells xenografted in NMRI nude mouse assessed as tumor growth inhibition at 10 mg/kg, po administered twice daily for 44 days | Homo sapiens | 1 | ALA5260844 | organism-based format | Scientific Literature | |
14. | ALA5264773 | Toxicity | Binding affinity to hERG (unknown origin) | Homo sapiens | 1 | ALA5260844 | assay format | Scientific Literature | |
15. | ALA5264774 | Physicochemical | Stability of the compound at pH 1 | 1 | ALA5260844 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA5264775 | Physicochemical | Stability of the compound at pH 7 | 1 | ALA5260844 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA5264776 | Physicochemical | Stability of the compound at pH 10 | 1 | ALA5260844 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA5264777 | ADME | Efflux ratio of permeability in human Caco-2 cells | Homo sapiens | 1 | ALA5260844 | cell-based format | Scientific Literature | |
19. | ALA5264778 | ADME | Permeability across basolateral to apical side in human Caco-2 cells | Homo sapiens | 1 | ALA5260844 | cell-based format | Scientific Literature | |
20. | ALA5264779 | ADME | Permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 1 | ALA5260844 | cell-based format | Scientific Literature |