# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5225714 | B | Protac activity at VHL/MEK1/2 in human A549 cells assessed as MEK1/2 degradation at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA5223165 | cell-based format | Scientific Literature | |
2. | ALA5225715 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
3. | ALA5225716 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
4. | ALA5225717 | B | Induction of MEK1 degradation in human A549 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
5. | ALA5225718 | B | Induction of MEK2 degradation in human A549 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
6. | ALA5225719 | B | Induction of MEK1/2 degradation in human A-375 cells incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
7. | ALA5225720 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 24 hrs in presence of 3-(3-amino-2-fluorobenzyl)-4-methyl-7-(pyrimidin-2-yloxy)-2H-chromen-2-one by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
8. | ALA5225721 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 24 hrs in presence of (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
9. | ALA5225722 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 24 hrs in presence of MLN4924 by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
10. | ALA5225723 | B | Induction of MEK1/2 degradation in human A549 cells at 1 uM incubated for 24 hrs in presence of MG132 by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
11. | ALA5225724 | B | Induction of MEK1/2 degradation in human A549 cells assessed as reduction in pERK1/2 levels at 1 to 30 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
12. | ALA5225725 | F | Antiproliferative activity against human A549 cells incubated for 4 days by MTT assay | Homo sapiens | 1 | ALA5223165 | cell-based format | Scientific Literature | |
13. | ALA5225726 | F | Antiproliferative activity against human A-375 cells incubated for 4 days by MTT assay | Homo sapiens | 2 | ALA5223165 | cell-based format | Scientific Literature | |
14. | ALA5225727 | F | Selectivity ratio of IC50 for human A549 cells to IC50 for human A-375 cells | Homo sapiens | 1 | ALA5223165 | assay format | Scientific Literature | |
15. | ALA5225728 | F | Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth at 10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 3 | ALA5223165 | cell-based format | Scientific Literature |