| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5226009 | B | Inverse agonist activity at 6His-tagged RORC2 LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay | Homo sapiens | 13 | ALA5223178 | assay format | Scientific Literature | |
| 2. | ALA5226010 | F | Inhibition of IL-17A production in human Th17 cells incubated for 6 days by celltiter-glo method | Homo sapiens | 13 | ALA5223178 | cell-based format | Scientific Literature | |
| 3. | ALA5226011 | A | Clearance in human liver microsomes | Homo sapiens | 13 | ALA5223178 | microsome format | Scientific Literature | |
| 4. | ALA5226012 | A | Passive apparent permeability in MDCKII-LE cells | Canis lupus familiaris | 13 | ALA5223178 | cell-based format | Scientific Literature | |
| 5. | ALA5226013 | T | Displacement of [3H]-dofetilide from human ERG | Homo sapiens | 7 | ALA5223178 | assay format | Scientific Literature | |
| 6. | ALA5226014 | P | Lipophilicity, log D of the compound at pH 7.4 by reverse phase HPLC | 13 | ALA5223178 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA5226015 | B | Inverse agonist activity at 6His-tagged RORA LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay | Homo sapiens | 1 | ALA5223178 | assay format | Scientific Literature | |
| 8. | ALA5226016 | B | Inverse agonist activity at 6His-tagged RORB LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay | Homo sapiens | 1 | ALA5223178 | assay format | Scientific Literature | |
| 9. | ALA5226017 | F | Ex vivo drug penetration in human abdominal skin applied topically using flow-through diffusion cell assessed as compound flux through skin measured upto 24 hrs by LC-MS/MS based in vitro skin penetration assay | Homo sapiens | 1 | ALA5223178 | organism-based format | Scientific Literature | |
| 10. | ALA5226018 | F | Ex vivo drug penetration in human abdominal skin applied topically using flow-through diffusion cell assessed as compound concentration in skin epidermis measured upto 24 hrs by LC-MS/MS based in vitro skin penetration assay | Homo sapiens | 1 | ALA5223178 | organism-based format | Scientific Literature | |
| 11. | ALA5226019 | F | Ex vivo drug penetration in human abdominal skin applied topically using flow-through diffusion cell assessed as compound concentration in dermis layers measured upto 24 hrs by LC-MS/MS based in vitro skin penetration assay | Homo sapiens | 1 | ALA5223178 | organism-based format | Scientific Literature | |
| 12. | ALA5226020 | B | Antagonist activity at RORC2 in human HeLa cells assessed as reduction in NR activity at 1 to 10 uM relative to control | Homo sapiens | 1 | ALA5223178 | cell-based format | Scientific Literature | |
| 13. | ALA5226021 | B | Agonist activity at PXR in human HeLa cells assessed as increase in NR activity at 10 uM relative to control | Homo sapiens | 1 | ALA5223178 | cell-based format | Scientific Literature |
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