| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5238738 | B | Inhibition of human recombinant full length PAK2 assessed as phosphorylation FRET peptide substrate measured after 60 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 2. | ALA5238739 | B | Inhibition of human recombinant PAK1 assessed as phosphorylation FRET peptide substrate measured after 60 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 3. | ALA5238740 | B | PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as PAK1 degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5238741 | B | PROTAC activity at PAK1/CRBN in human OVACR-3 cells assessed as PAK1 degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5238742 | B | PROTAC activity at PAK2/CRBN in human MCF7 cells assessed as PAK1 degradation at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5238743 | B | PROTAC activity at PAK2/CRBN in human OVACR-3 cells assessed as PAK1 degradation at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5238744 | B | PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as PAK1 degradation measured at 10 nM by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5238745 | B | PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as PAK1 degradation in presence of bortezomib measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5238746 | B | PROTAC activity at PAK1/CRBN in human OVACR-3 cells assessed as PAK1 degradation in presence of bortezomib measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5238747 | F | Downregulation of ring-finger protein RNF166 expression in human MOLT-4 cells at 1 uM measured after 5 hrs by global multiplexed mass spectrometry-based proteomic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5238748 | F | Downregulation of EKZF1 expression in human MOLT-4 cells at 1 uM measured after 5 hrs by global multiplexed mass spectrometry-based proteomic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5238749 | F | Downregulation of IKZF3 expression in human MOLT-4 cells at 1 uM measured after 5 hrs by global multiplexed mass spectrometry-based proteomic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5238750 | B | PROTAC activity at PAK1/CRBN in HEK293 cells transfected with Nluc-tagged PAK1 assessed as PAK1 degradation by measuring luciferase activity at 10 nM by Nano-Glo live cell assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5238751 | B | PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as MEK phosphorylation at S298 at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA5238752 | B | PROTAC activity at PAK1/CRBN in human MCF7 cells assessed as ERK phosphorylation at Thr202/Tyr204 at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA5238753 | B | PROTAC activity at PAK1/CRBN in human OVACR3 cells assessed as MEK phosphorylation at S298 at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA5238754 | B | PROTAC activity at PAK1/CRBN in human OVACR3 cells assessed as ERK phosphorylation at Thr202/Tyr204 at 10 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA5238755 | F | Antiproliferative activity against human OVCAR-3 cells assessed as cell viability measured after 72 hrs incubation by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA5238756 | F | Antiproliferative activity against human MCF7 cells assessed as cell viability measured after 72 hrs incubation by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA5238757 | F | Antiproliferative activity against human OMM-1 cells assessed as cell viability measured after 72 hrs incubation by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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