| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5247163 | ADME | Metabolic stability in mouse liver microsomes assessed as clearance at 1 uM measured upto 30 mins in the presence of NADPH-generating system by LC-MS analysis | Mus musculus | 9 | ALA5244276 | microsome format | Scientific Literature | |
| 2. | ALA5247164 | Binding | Displacement of [3H]spermidine trihydrochloride from N-terminal 6his tagged TEV fused human DHPS expressed in Escherichia coli BL21 (DE3) incubated for 120 mins in the presence of 14 uM NAD+ by radiometric assay | Homo sapiens | 22 | ALA5244276 | assay format | Scientific Literature | |
| 3. | ALA5247165 | Binding | Displacement of [3H]spermidine trihydrochloride from N-terminal 6his tagged TEV fused human DHPS expressed in Escherichia coli BL21 (DE3) incubated for 120 mins in the presence of 250 uM NAD+ by radiometric assay | Homo sapiens | 9 | ALA5244276 | assay format | Scientific Literature | |
| 4. | ALA5247166 | ADME | Volume of distribution at steady state in ICR mouse at 0.1 mg/kg, iv administered as cassette dose and measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature | |
| 5. | ALA5247167 | ADME | Total clearance in ICR mouse at 0.1 mg/kg, iv administered as cassette dose and measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature | |
| 6. | ALA5247168 | ADME | Cmax in ICR mouse at 1 mg/kg, po administered as cassette dose and measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature | |
| 7. | ALA5247169 | ADME | AUC in ICR mouse at 1 mg/kg, po administered as cassette dose and measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature | |
| 8. | ALA5247170 | ADME | MRT in ICR mouse at 1 mg/kg, po administered as cassette dose and measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature | |
| 9. | ALA5247171 | ADME | Bioavailability in ICR mouse measured upto 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5244276 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!