| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5263771 | Binding | Positive allosteric modulation of human GABAA alpha1beta2gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assay | Homo sapiens | 2 | ALA5260830 | cell-based format | Scientific Literature | |
| 2. | ALA5263772 | Binding | Positive allosteric modulation of human GABAA alpha2beta1gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assay | Homo sapiens | 2 | ALA5260830 | cell-based format | Scientific Literature | |
| 3. | ALA5263773 | Physicochemical | Solubility of the compound in 45% HPbetaCD | 2 | ALA5260830 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA5263774 | ADME | Oral availability in rat 3 mg/kg, po | Rattus norvegicus | 1 | ALA5260830 | organism-based format | Scientific Literature | |
| 5. | ALA5263775 | Functional | Anxiolytic activity in mouse assessed as increase in time spent in open arm by elevated plus maze test | Mus musculus | 2 | ALA5260830 | organism-based format | Scientific Literature | |
| 6. | ALA5263776 | Functional | Anticonvulsant activity in PTZ induced mouse administered orally | Mus musculus | 2 | ALA5260830 | organism-based format | Scientific Literature | |
| 7. | ALA5263777 | Toxicity | Therapeutic index, ratio of AD50 for mouse to MED for anxiolytic activity in mouse assessed as increase in time spent in open arm by elevated plus maze test | 2 | ALA5260830 | assay format | Scientific Literature | ||
| 8. | ALA5263778 | Toxicity | Therapeutic index, ratio of AD50 for mouse to ED50 for anticonvulsant activity in PTZ induced mouse administered orally | 2 | ALA5260830 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!