| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5253113 | B | Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO-K1 cells incubated for 1 hr by 1450 microbeta scintillation counter analysis | Homo sapiens | 79 | cell-based format | Scientific Literature | ||
| 2. | ALA5253114 | B | Selectivity ratio, ratio of Ki for human KOR to Ki for human NOP | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 3. | ALA5253115 | B | Selectivity ratio, ratio of Ki for human KOR to Ki for human DOR | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 4. | ALA5253116 | B | Selectivity ratio, ratio of Ki for human KOR to Ki for human MOR | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 5. | ALA5253118 | B | Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as ERK phosphorylation incubated for 2 hrs by Alphascreen surefire method | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 6. | ALA5253119 | B | Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production incubated for 30 mins by LANCE cAMP assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 7. | ALA5253120 | A | Metabolic stability in Wistar rat plasma assessed as half life by HPLC analysis | Rattus norvegicus | 28 | cell-free format | Scientific Literature | ||
| 8. | ALA5253126 | A | Metabolic stability in Wistar rat plasma assessed as BzPrrQ[CHA]CC formation by measuring relative abundance measuring after 360 mins by HPLC analysis relative to control | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 9. | ALA5253127 | A | Metabolic stability in Wistar rat plasma assessed as BzPrrQ[CHA] formation by measuring relative abundance measuring after 360 mins by HPLC analysis relative to control | Rattus norvegicus | 1 | cell-free format | Scientific Literature | ||
| 10. | ALA5253130 | F | Antinociceptive activity against C57BL/6 mouse model of TNBS induced chronic visceral hypersensitivity assessed as inhibition of colonic nociceptor mechanosensitivity at 1000 nM, administered topically on colon mucosal surface for 28 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA5253131 | F | Antinociceptive activity against C57BL/6 mouse model of TNBS induced chronic visceral hypersensitivity assessed as inhibition of colonic nociceptor mechanosensitivity at 1000 nM, administered topically on colon mucosal surface for 28 days in presence of norbinaltorphimine | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5253132 | F | Antinociceptive activity against C57BL/6 mouse assessed as inhibition of colonic nociceptor mechanosensitivity at 1 to 1000 nM, administered topically on colon mucosal surface for 28 days | Mus musculus | 1 | organism-based format | Scientific Literature |
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