# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5249644 | Binding | Inhibition of human glutaminyl cyclase using L-glutamine-7-amido-4-methylcoumarin as substrate incubated for 10 mins in presence of pyroglutamyl peptidase by fluorometry analysis | Homo sapiens | 35 | ALA5247605 | single protein format | Scientific Literature | |
2. | ALA5249645 | Toxicity | Cytotoxicity against mouse HT-22 cells assessed as cell viability at 10 uM incubated for 18 hrs by MTT assay relative to control | Mus musculus | 16 | ALA5247605 | cell-based format | Scientific Literature | |
3. | ALA5249646 | Toxicity | Inhibition of hERG at 10 uM by fluorescence polarization assay relative to control | Homo sapiens | 16 | ALA5247605 | assay format | Scientific Literature | |
4. | ALA5249647 | Toxicity | Inhibition of hERG by fluorescence polarization assay | Homo sapiens | 11 | ALA5247605 | assay format | Scientific Literature | |
5. | ALA5249648 | ADME | Effective permeability coefficient by PAMPA-BBB assay | 16 | ALA5247605 | assay format | Scientific Literature | ||
6. | ALA5249650 | Functional | Antialzheimer activity in human amyloid beta (3 to 40 residues) induced ICR mouse model assessed as inhibition of pyroglutamate form of amyloid-beta formation in brain at 10 mM, icv by sandwich ELISA relative to control | Mus musculus | 8 | ALA5247605 | organism-based format | Scientific Literature | |
7. | ALA5249651 | Binding | Inhibition of isoQC (unknown origin) | Homo sapiens | 3 | ALA5247605 | single protein format | Scientific Literature | |
8. | ALA5249652 | Binding | Inhibition of mouse glutaminyl cyclase | Mus musculus | 3 | ALA5247605 | single protein format | Scientific Literature | |
9. | ALA5249653 | ADME | Metabolic stability in human liver microsomes assessed as compound remaining after 30 mins | Homo sapiens | 3 | ALA5247605 | microsome format | Scientific Literature | |
10. | ALA5249654 | ADME | Metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins | Mus musculus | 3 | ALA5247605 | microsome format | Scientific Literature |