| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5243014 | Binding | Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 cells assessed as reduction in ADP production preincubated for 20 mins followed by substrate addition and measured after 60 mins using Dic8-PI5P as substrate in presence of 10 uM ATP by ADP-Glo luminescent assay | Homo sapiens | 56 | ALA5241108 | cell-based format | Scientific Literature | |
| 2. | ALA5243015 | Binding | Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 assessed as reduction in PI4,5P2 production preincubated for 20 mins followed by substrate addition and measured after 60 mins using Dic8-PI5P as substrate in presence of 10 uM ATP by HTRF assay | Homo sapiens | 56 | ALA5241108 | cell-based format | Scientific Literature | |
| 3. | ALA5243016 | Binding | Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 cells assessed as reduction in ADP production preincubated for 20 mins followed by substrate addition and measured after 60 mins using Dic8-PI5P as substrate in presence of 250 uM ATP by ADP-Glo luminescent assay | Homo sapiens | 56 | ALA5241108 | cell-based format | Scientific Literature | |
| 4. | ALA5243017 | Binding | Inhibition of recombinant full length His-tagged PIP4K2A (unknown origin) expressed in sf21 assessed as reduction in PI4,5P2 production preincubated for 20 mins followed by substrate addition and measured after 60 mins using Dic8-PI5P as substrate in presence of 2 mM ATP by HTRF assay | Homo sapiens | 56 | ALA5241108 | cell-based format | Scientific Literature | |
| 5. | ALA5243018 | Binding | Inhibition of human PIP4K2A in human THP-1 cells assessed as increase in Akt phosphorylation at Ser473 residue incubated for 2 hrs by HTRF assay | Homo sapiens | 56 | ALA5241108 | cell-based format | Scientific Literature | |
| 6. | ALA5243020 | Physicochemical | Lipophilicity, logD of compound at pH 7.5 by reversed-phase HPLC analysis | 52 | ALA5241108 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA5243021 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells at 2 uM measured after 2 hrs by LC/MS-MS analysis | Homo sapiens | 21 | ALA5241108 | cell-based format | Scientific Literature | |
| 8. | ALA5243023 | ADME | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells at 2 uM measured after 2 hrs by LC/MS-MS analysis | Homo sapiens | 14 | ALA5241108 | cell-based format | Scientific Literature |
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