| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239154 | B | Inhibition of C-terminal FLAG-His8-tagged full length human CTPS1 preincubated for 10 mins followed by substrate addition by ADP-Glo assay | Homo sapiens | 34 | single protein format | Scientific Literature | ||
| 2. | ALA5239155 | F | Antiproliferative activity against human Jurkat E6.1 cells after 3 days by luminescence based CellTiter-glo assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
| 3. | ALA5239156 | P | Dissociation constant, pKa of the compound by UV spectra analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA5239158 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells at 10 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA5239159 | A | Efflux ratio of apparent permeability in human Caco-2 cells | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA5239160 | A | Stability in mouse hepatocytes assessed as clearance per 10^6 cells at 1 uM measured upto 60 mins by LC-MS/MS method | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA5239161 | A | Cmax in CD-1 mouse at 10 mg/kg, po | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA5239162 | A | AUC(0 to t) in CD-1 mouse at 10 mg/kg, po | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA5239163 | A | Oral bioavailability in CD-1 mouse at 10 mg/kg | Mus musculus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA5239168 | P | Lipophilicity, logD of the compound at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA5239169 | A | Unbound fraction in mouse plasma | Mus musculus | 1 | cell-free format | Scientific Literature | ||
| 12. | ALA5239170 | P | Thermodynamic solubility of compound at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA5239171 | B | Inhibition of human CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA5239172 | B | Inhibition of human CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA5239173 | B | Selectivity ratio of IC50 for human CTPS2 to IC50 for human CTPS1 | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 16. | ALA5239174 | B | Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Rattus norvegicus | 4 | single protein format | Scientific Literature | ||
| 17. | ALA5239175 | B | Inhibition of rat CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 18. | ALA5239176 | B | Selectivity ratio of IC50 for rat CTPS2 to IC50 for rat CTPS1 | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 19. | ALA5239177 | B | Inhibition of mouse CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Mus musculus | 4 | single protein format | Scientific Literature | ||
| 20. | ALA5239178 | B | Inhibition of mouse CTPS1 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assay | Mus musculus | 4 | single protein format | Scientific Literature |
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