The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
The page will load shortly, Thanks for your patience!
# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA5239593 B Displacement of (E)-S-phenyl 3(4-hydroxy-3,5-dimethylstyryl)benzothioate from human plasma TTR at 20 uM incubated for 6 hrs by fluorescence based assay Homo sapiens 6 cell-free format Scientific Literature 2. ALA5239594 B Inhibition of acid mediated TTR V30M mutant aggregation (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by acid stimulation and measured after 96 hrs by fluorescence spectrophotometer analysis Homo sapiens 13 assay format Scientific Literature 3. ALA5239595 B Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli by ITC assay Homo sapiens 6 assay format Scientific Literature 4. ALA5239596 B Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as gibbs free energy change by ITC assay Homo sapiens 6 assay format Scientific Literature 5. ALA5239597 B Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as change in enthalpy by ITC assay Homo sapiens 6 assay format Scientific Literature 6. ALA5239598 B Binding affinity to TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as change in entropy by ITC assay Homo sapiens 6 assay format Scientific Literature 7. ALA5239599 P Aqueous solubility of compound at pH 1.2 incubated for 4 hrs 1 small-molecule physicochemical format Scientific Literature 8. ALA5239600 P Aqueous solubility of compound at pH 6.8 incubated for 4 hrs 1 small-molecule physicochemical format Scientific Literature 9. ALA5239601 A Permeability of compound at 10 uM after 4 hrs by LC-MS/MS based PAMPA 1 assay format Scientific Literature 10. ALA5239602 A Stability in rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 30 mins by LC-MS/MS analysis Rattus norvegicus 1 microsome format Scientific Literature 11. ALA5239603 A Plasma protein binding in rat assessed as unbound fraction at 1 uM incubated for 4 hrs by rapid equilibrium dialysis method Rattus norvegicus 1 cell-free format Scientific Literature 12. ALA5239604 A Drug concentration in Sprague-Dawley rat plasma at 1 mg/kg, iv after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 13. ALA5239605 A Drug concentration in Sprague-Dawley rat plasma at 1 mg/kg, po after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 14. ALA5239606 A Drug concentration in Sprague-Dawley rat eye ball at 1 mg/kg, iv after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 15. ALA5239607 A Drug concentration in Sprague-Dawley rat eye ball at 1 mg/kg, po after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 16. ALA5239608 A Drug concentration in Sprague-Dawley rat brain at 1 mg/kg, iv after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 17. ALA5239609 A Drug concentration in Sprague-Dawley rat brain at 1 mg/kg, po after 8 hrs by LC-MS/MS anlaysis Rattus norvegicus 1 organism-based format Scientific Literature 18. ALA5239610 A Ratio of drug concentration in Sprague-Dawley rat eye ball to plasma at 1 mg/kg, iv after 8 hrs by LC-MS/MS analysis Rattus norvegicus 1 organism-based format Scientific Literature 19. ALA5239611 A Ratio of drug concentration in Sprague-Dawley rat eye ball to plasma at 1 mg/kg, po after 8 hrs by LC-MS/MS analysis Rattus norvegicus 1 organism-based format Scientific Literature 20. ALA5239612 A Ratio of drug concentration in Sprague-Dawley rat brain to plasma at 1 mg/kg, iv after 8 hrs by LC-MS/MS analysis Rattus norvegicus 1 organism-based format Scientific Literature