| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5229239 | B | Inhibition of Mycobacterium tuberculosis recombinant PknB (1 to 331 residues) expressed in Escherichia coli BL21-Rosetta cells using GarA and ATP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured after 1 hr by ATP-competitive biochemical assay | Mycobacterium tuberculosis | 18 | cell-based format | Scientific Literature | ||
| 2. | ALA5229240 | B | Binding affinity to Mycobacterium tuberculosis recombinant N-terminal His-tagged PknB (1 to 331 residues) expressed in Escherichia coli DH5alpha cells by microscale thermophoresis analysis | Mycobacterium tuberculosis | 18 | cell-based format | Scientific Literature | ||
| 3. | ALA5229241 | T | Inhibition of human Cdk2/Cyclin A using Myelin basic protein as substrate by ATP competitive assay | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 4. | ALA5229242 | B | Binding affinity to Mycobacterium tuberculosis partial length PknB (M1 to G279 residues) expressed in mammalian expression system by KdELECT kinase assay | Mycobacterium tuberculosis | 5 | assay format | Scientific Literature | ||
| 5. | ALA5229243 | T | Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 6. | ALA5229244 | T | Binding affinity to human full length GSK-3 beta (M1 to T433 residues) expressed in mammalian expression system by KdELECT kinase assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA5229245 | T | Binding affinity to human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by KdELECT kinase assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA5229246 | T | Binding affinity to human partial length Pim1 (A15 to K313 residues ) expressed in bacterial expression system by KdELECT kinase assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 9. | ALA5229251 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 assessed as inhibition of bacterial growth incubated for 12 days by Alamar Blue based fluorescence analysis | Mycobacterium tuberculosis | 9 | organism-based format | Scientific Literature | ||
| 10. | ALA5229252 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth incubated for 12 days by Alamar Blue based fluorescence analysis | Mycobacterium tuberculosis | 9 | organism-based format | Scientific Literature | ||
| 11. | ALA5229253 | P | Lipophilicity, logD of the compound in octanol and phosphate buffer at pH 7.4 at 66.7 uM by LC-MS/MS analysis | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA5229254 | T | Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo luminescent assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 13. | ALA5229255 | T | Toxicity against Zebrafish embryo assessed as embryo survival at 5 uM incubated for 5 days and measured daily | Danio rerio | 9 | assay format | Scientific Literature |
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