| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5260303 | B | Inhibition of Nrf2-Keap1 Kelch domain (unknown origin) protein-protein interaction in presence of biotin labeled 16mer ETGE peptide AFFAQLQLDEETGEFL | Homo sapiens | 21 | ALA5257130 | protein format | Scientific Literature | |
| 2. | ALA5260304 | A | Solubility of compound in FASSIF at pH 6.5 incubated for 4 hrs by LC/MS analysis | 3 | ALA5257130 | assay format | Scientific Literature | ||
| 3. | ALA5260305 | A | Solubility of compound in FeSSIF at pH 5 incubated for 4 hrs by LC/MS analysis | 3 | ALA5257130 | assay format | Scientific Literature | ||
| 4. | ALA5260306 | A | Apparent permeability in human Caco-2 cells at 25 micromol/L incubated for 2 hrs by LC/MS/MS analysis | Homo sapiens | 12 | ALA5257130 | cell-based format | Scientific Literature | |
| 5. | ALA5260307 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 5 uM measured after 60 mins | Homo sapiens | 3 | ALA5257130 | microsome format | Scientific Literature | |
| 6. | ALA5260308 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 5 uM measured after 60 mins | Rattus norvegicus | 3 | ALA5257130 | microsome format | Scientific Literature | |
| 7. | ALA5260309 | F | Upregulation of HO-1 expression in human HRMC cells incubated for 18 hrs by ELISA assay | Homo sapiens | 5 | ALA5257130 | cell-based format | Scientific Literature | |
| 8. | ALA5260310 | B | Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in free energy by isothermal titration calorimetry assay | Homo sapiens | 3 | ALA5257130 | single protein format | Scientific Literature | |
| 9. | ALA5260311 | B | Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in enthalpy by isothermal titration calorimetry assay | Homo sapiens | 3 | ALA5257130 | single protein format | Scientific Literature | |
| 10. | ALA5260312 | B | Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in entropy by isothermal titration calorimetry assay | Homo sapiens | 3 | ALA5257130 | single protein format | Scientific Literature | |
| 11. | ALA5260313 | A | MRT in CD(SD) rat at 1 mg/kg, iv measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 12. | ALA5260314 | A | MRT in CD(SD) rat at 3 mg/kg, po measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 13. | ALA5260315 | A | Half life in CD(SD) rat at 1 mg/kg, iv measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 14. | ALA5260316 | A | Tmax in CD(SD) rat at 3 mg/kg, po measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 15. | ALA5260317 | A | Total clearance in CD(SD) rat at 1 mg/kg, iv measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 16. | ALA5260318 | A | Volume of distribution in CD(SD) rat at 1 mg/kg, iv measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 17. | ALA5260319 | A | AUC in CD(SD) rat at 1 mg/kg, iv measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 18. | ALA5260320 | A | AUC in CD(SD) rat at 3 mg/kg, po measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 19. | ALA5260321 | A | Oral bioavailability in CD(SD) rat at 3 mg/kg measured upto 25 hrs | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature | |
| 20. | ALA5260322 | F | Invivo inhibition of Nrf2-Keap1 Kelch domain protein-protein interaction in po dosed Wistar rat kidney assessed as increase in HO-1 protein level incubated for 6 hrs by ELISA assay | Rattus norvegicus | 1 | ALA5257130 | organism-based format | Scientific Literature |
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