# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5250787 | P | Thermodynamic aqueous solubility of compound at 25 degreeC measured after 24 hrs by HPLC analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
2. | ALA5250788 | B | Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Leishmania infantum | 17 | assay format | Scientific Literature | ||
3. | ALA5250789 | B | Disruption of HIS-FLAG-tagged recombinant Leishmania infantum TryR dimerization expressed in Escherichia coli Rossetta BL21 (DE3) cells incubated for 16 hrs by ELISA analysis | Leishmania infantum | 17 | cell-based format | Scientific Literature | ||
4. | ALA5250791 | B | Inhibition of HIS-tagged recombinant Trypanosoma brucei TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Trypanosoma brucei | 3 | assay format | Scientific Literature | ||
5. | ALA5250792 | B | Inhibition of HIS-tagged recombinant Trypanosoma cruzi TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Trypanosoma cruzi | 3 | assay format | Scientific Literature | ||
6. | ALA5250793 | B | Inhibition of HIS-tagged recombinant Trypanosoma congolense TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Trypanosoma congolense | 3 | assay format | Scientific Literature | ||
7. | ALA5250794 | B | Inhibition of HIS-tagged recombinant human GR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
8. | ALA5250795 | B | Competitive inhibition of HIS-FLAG-tagged recombinant Leishmania infantum TryR expressed in Escherichia coli using TS2 substrate assessed as inhibition constant in the presence of NADPH by spectrophotometry based DTNB-coupled assay | Leishmania infantum | 1 | assay format | Scientific Literature | ||
9. | ALA5250796 | B | Competitive inhibition of HIS-FLAG-tagged recombinant Leishmania infantum TryR expressed in Escherichia coli assessed as dissociation constant by SPR assay | Leishmania infantum | 1 | assay format | Scientific Literature | ||
10. | ALA5250797 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes assessed as reduction in parasite viability treated for 24 hrs by PI staining based flow cytometry | Leishmania infantum | 17 | organism-based format | Scientific Literature | ||
11. | ALA5250798 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation treated for 24 hrs by crystal violet staining based analysis | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
12. | ALA5250799 | T | Selectivity index, ratio of CC50 for human HepG2 cells to EC50 for Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes | 18 | assay format | Scientific Literature |