# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5250194 | B | Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in Bac-to-Bac baculovirus expression system measured after 2 hrs by ELISA method | Homo sapiens | 38 | ALA5247618 | assay format | Scientific Literature | |
2. | ALA5250195 | F | Antiproliferative activity against mouse BaF3 cells harboring EGFR 19del/T790M/C797S triple mutant after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5247618 | cell-based format | Scientific Literature | |
3. | ALA5250196 | F | Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant after 72 hrs by CCK-8 assay | Mus musculus | 11 | ALA5247618 | cell-based format | Scientific Literature | |
4. | ALA5250199 | B | Inhibition of EGFR 19del/T790M/C797S triple mutant phosphorylation in mouse BaF3 cells assessed as Akt down stream singling at 10000 nM by Western blotting analysis | Mus musculus | 2 | ALA5247618 | cell-based format | Scientific Literature | |
5. | ALA5250202 | B | Inhibition of EGFR phosphorylation in mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant at1 to 10000 nM by Western blotting analysis | Mus musculus | 1 | ALA5247618 | cell-based format | Scientific Literature | |
6. | ALA5250203 | B | Inhibition of EGFR phosphorylation in mouse BaF3 cells harboring EGFR 19del/T790M/C797S triple mutant at 100 nM by Western blotting analysis | Mus musculus | 1 | ALA5247618 | cell-based format | Scientific Literature | |
7. | ALA5250204 | B | Inhibition of ERK downstream signalling pathway in mouse BaF3 cells harboring EGFR 19del/T790M/C797S triple mutant by Western blot analysis | Mus musculus | 1 | ALA5247618 | cell-based format | Scientific Literature | |
8. | ALA5250205 | B | Binding affinity to EGFR L858R/T790M/C797S triple mutant (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
9. | ALA5250206 | B | Binding affinity to EGFR 19del/T790M/C797S triple mutant (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
10. | ALA5250207 | B | Binding affinity to BLK (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
11. | ALA5250208 | B | Binding affinity to ERRB2 (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
12. | ALA5250209 | B | Binding affinity to ERRB3 (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
13. | ALA5250210 | B | Binding affinity to FLT D835V mutant (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | assay format | Scientific Literature | |
14. | ALA5250211 | B | Binding affinity to FLT N8411 mutant (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | assay format | Scientific Literature | |
15. | ALA5250212 | B | Binding affinity to LCK (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | single protein format | Scientific Literature | |
16. | ALA5250213 | B | Binding affinity to MEK5 (unknown origin) assessed as strong interaction at 100 nM | Homo sapiens | 1 | ALA5247618 | assay format | Scientific Literature | |
17. | ALA5250214 | A | Bioavailability in Sprague-Dawley rat at 10 mg/kg, po or 1 mg/kg, iv measured at 0.083 to 14 hrs by LC-MS/MS-13 analysis relative to control | Rattus norvegicus | 1 | ALA5247618 | organism-based format | Scientific Literature | |
18. | ALA5250215 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, iv measured at 0.083 to 14 hrs by LC-MS/MS-13 analysis | Rattus norvegicus | 1 | ALA5247618 | organism-based format | Scientific Literature | |
19. | ALA5250216 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured at 0.25 to 14 hrs by LC-MS/MS-13 analysis | Rattus norvegicus | 1 | ALA5247618 | organism-based format | Scientific Literature | |
20. | ALA5250217 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv measured at 0.083 to 14 hrs by LC-MS/MS-13 analysis | Rattus norvegicus | 1 | ALA5247618 | organism-based format | Scientific Literature |