| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5239394 | B | Inhibition of recombinant N-terminal GST-tagged human DLK (9 to 111 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylation using MKK4 and ATP as substrate incubated for 1.5 hrs by HTRF analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA5239395 | B | Inhibition of recombinant N-terminal GST-tagged human LZK (9 to 114 residues) expressed in Sf21 cells assessed as reduction in substrate phosphorylation using MKK4 and ATP as substrate incubated for 1.5 hrs by HTRF analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA5239396 | B | Inhibition of human DLK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulation and measured after 24 hrs by MSD ELISA | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA5239397 | B | Inhibition of human LZK expressed in HEK cells assessed as reduction in phospho-c-Jun level preincubated for 45 mins followed by doxycycline stimulation and measured after 24 hrs by MSD ELISA | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 5. | ALA5239398 | A | Microsomal stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 15 | microsome format | Scientific Literature | ||
| 6. | ALA5239399 | A | Efflux ratio of permeability across basolateral to apical side over apical to basolateral side in dog MDCK-MDR1 cells expressing human P-glycoprotein | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 7. | ALA5239400 | F | Neuroprotective activity against CD-1 mouse DRG neurons transfected with mCherry assessed as reduction in axonal degeneration at 1 uM incubated for 20 hrs in NGF deprived medium by fluorescence microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5239401 | F | Neuroprotective activity against CD-1 mouse DRG neurons transfected with mCherry assessed as reduction in caspase activation at 1 uM incubated for 20 hrs in NGF deprived medium by fluorescence microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5239402 | F | Neuroprotective activity against CD-1 mouse DRG neurons transfected with mCherry assessed as reduction in axonal degeneration at 0.1 to 0.3 uM incubated for 20 hrs in NGF deprived medium by fluorescence microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5239403 | F | Neuroprotective activity against CD-1 mouse DRG neurons transfected with mCherry assessed as reduction in caspase activation at 0.1 to 0.3 uM incubated for 20 hrs in NGF deprived medium by fluorescence microscopic analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5239404 | A | Cmax in Sprague-Dawley rat plasma at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA5239405 | A | AUC (0-24hrs) in Sprague-Dawley rat plasma at 1 mg/kg, iv and measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA5239406 | A | Clearance in Sprague-Dawley rat plasma at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA5239407 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA5239408 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA5239409 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA5239410 | A | Ratio of unbound drug level in Sprague-Dawley rat brain to plasma at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA5239411 | A | AUC (0-2 hrs) in Sprague-Dawley rat brain at 1 mg/kg, iv and measured upto 2 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5239412 | A | Cmax in Sprague-Dawley rat plasma at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA5239413 | A | AUC (0-24hrs) in Sprague-Dawley rat plasma at 3 mg/kg, po and measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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